Williams Jessica L, Perry Jamie L, Singh Davinder J, Sitzman Thomas J
Phoenix Children's Center for Cleft and Craniofacial, Phoenix Children's Hospital, Phoenix, AZ, USA.
Division of Plastic Surgery, Phoenix Children's Hospital, Phoenix, AZ, USA.
Cleft Palate Craniofac J. 2024 Jul 26:10556656241266365. doi: 10.1177/10556656241266365.
Compare the effectiveness of palatoplasty and pharyngoplasty procedures at resolving hypernasality in patients with 22q11.2 deletion syndrome (22q).
Retrospective cohort study.
Metropolitan children's hospital.
Fourteen patients with 22q presenting for management of velopharyngeal insufficiency.
Palatoplasty or pharyngoplasty procedure.
Resolution of hypernasality 12 months postoperatively.
Both procedure groups had a mean preoperative velopharyngeal gap of 6.2 mm during phonation. No patient who underwent palatoplasty achieved resolution of hypernasality; 1/7 patients had worse hypernasality, 4/7 had no change, and 2/7 had improved hypernasality. In contrast, hypernasality was resolved in 6/7 patients in the pharyngoplasty group, which was significantly ( = .03) higher than the palatoplasty group.
In patients with 22q, palatoplasty procedures may be less effective than pharyngoplasty procedures at resolving hypernasality. This may be due to underlying anatomic or physiologic differences, such as increased pharyngeal depth and hypodynamic muscles.
比较腭裂修复术和咽成形术对22q11.2缺失综合征（22q）患者鼻音过重问题的解决效果。
回顾性队列研究。
大都市儿童医院。
14例因腭咽功能不全前来治疗的22q患者。
腭裂修复术或咽成形术。
术后12个月鼻音过重问题的解决情况。
两组手术患者在发声时术前腭咽间隙平均为6.2毫米。接受腭裂修复术的患者中，无一人解决了鼻音过重问题；7例患者中，1例鼻音过重情况恶化，4例无变化，2例有所改善。相比之下，咽成形术组7例患者中有6例解决了鼻音过重问题，显著高于腭裂修复术组（P = 0.03）。
对于22q患者，腭裂修复术在解决鼻音过重问题上可能不如咽成形术有效。这可能是由于潜在的解剖或生理差异，如咽深度增加和肌肉动力不足。
