Do Palatoplasty Procedures Resolve Hypernasality as Effectively as Pharyngoplasty Procedures in Patients with 22q11.2 Deletion Syndrome?

OBJECTIVE

Compare the effectiveness of palatoplasty and pharyngoplasty procedures at resolving hypernasality in patients with 22q11.2 deletion syndrome (22q).

DESIGN

Retrospective cohort study.

SETTING

Metropolitan children's hospital.

PATIENTS

Fourteen patients with 22q presenting for management of velopharyngeal insufficiency.

INTERVENTIONS

Palatoplasty or pharyngoplasty procedure.

MAIN OUTCOME MEASURE

Resolution of hypernasality 12 months postoperatively.

RESULTS

Both procedure groups had a mean preoperative velopharyngeal gap of 6.2 mm during phonation. No patient who underwent palatoplasty achieved resolution of hypernasality; 1/7 patients had worse hypernasality, 4/7 had no change, and 2/7 had improved hypernasality. In contrast, hypernasality was resolved in 6/7 patients in the pharyngoplasty group, which was significantly ( = .03) higher than the palatoplasty group.

CONCLUSIONS

In patients with 22q, palatoplasty procedures may be less effective than pharyngoplasty procedures at resolving hypernasality. This may be due to underlying anatomic or physiologic differences, such as increased pharyngeal depth and hypodynamic muscles.