University of Zimbabwe, Faculty of Medicine & Health Sciences, Harare, Zimbabwe.
Department of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Rd, Cape Town, 7700, South Africa.
Future Oncol. 2024;20(26):1909-1924. doi: 10.1080/14796694.2024.2375959. Epub 2024 Jul 26.
To describe treatment-induced toxicities (TITs) and associated factors in Zimbabwean cancer patients receiving cisplatin. In total, 252 Zimbabwean women with cervical cancer, receiving cisplatin were followed up over 12 months for TITs and disease status. Peripheral neuropathy (70%) and ototoxicity (53%) were most prevalent. Advanced disease (OR = 1.3; 95% CI = 1.1-1.5; p = 0.02), pain comedications (OR = 1.3; 95% CI = 1.1-1.5; p = 0.03), alcohol (OR = 2.8; 95% CI = 1.1-7.5; p = 0.04) and comorbidities (OR = 1.2; 95% CI = 1.1-1.4; p = 0.04) increased peripheral neuropathy and ototoxicity risk. Older age increased risk of disease progression (OR = 1.9; 95% CI = 1.4-3.0; p = 0.033). High peripheral neuropathy and ototoxicity prevalence were observed, which are not routinely monitored in Zimbabwe. There is a need for capacity building to incorporate comprehensive TIT testing and optimize cancer care in Zimbabwe.
描述津巴布韦接受顺铂治疗的癌症患者的治疗相关毒性（TITs）及其相关因素。总共对 252 名接受顺铂治疗的津巴布韦宫颈癌女性患者进行了为期 12 个月的 TITs 和疾病状况随访。周围神经病变（70%）和耳毒性（53%）最为常见。晚期疾病（OR=1.3；95%CI=1.1-1.5；p=0.02）、疼痛合并用药（OR=1.3；95%CI=1.1-1.5；p=0.03）、饮酒（OR=2.8；95%CI=1.1-7.5；p=0.04）和合并症（OR=1.2；95%CI=1.1-1.4；p=0.04）增加了周围神经病变和耳毒性的风险。年龄越大，疾病进展的风险越高（OR=1.9；95%CI=1.4-3.0；p=0.033）。观察到高周围神经病变和耳毒性发生率，但津巴布韦并未常规监测这些毒性。因此，需要进行能力建设，以纳入全面的 TIT 检测并优化津巴布韦的癌症护理。
