Kuguyo Oppah, Tsikai Nomsa, Muradzikwa Senelisiwe Chipo, Mhandire Kudakwashe, Nhachi Charles, Magwali Thulani, Madziyire Mugove G, Matimba Alice, Dandara Collet
University of Zimbabwe College of Health Sciences, Department of Clinical Pharmacology, Avondale, Harare, Zimbabwe.
University of Cape Town, Faculty of Health Sciences Department of Pathology, Human Genetics Division, 1 Anzio Rd, Observatory, Cape Town, South Africa.
Afr J Reprod Health. 2021 Dec;25(6):99-109. doi: 10.29063/ajrh2021/v25i6.11.
Cervical cancer is the leading cause of cancer deaths in women in Africa, predominately due to late diagnosis. This study aims to identify risk factors, potential prognostic indicators, and optimal treatment modalities for Zimbabwean cervical cancer patients. Medical records for 1063 cervical cancer patients were reviewed for sociodemographic, clinical, treatment, and response data. All data were analysed using SPSS version 25. More than half of the cohort was pre-menopausal (63%) with low (2%) history of cervical cancer screening. Schistosoma ova were observed in 2.4% of the tumour specimens. More than 50% were diagnosed at stage 3 and later, with a high frequency of comorbidities (~68%). This study highlights a need for improving screening education and uptake in Zimbabwe. Moreover, the current data provides a dataset for understanding cervical cancer pathogenesis and treatment responses in an African cohort.
宫颈癌是非洲女性癌症死亡的主要原因，主要是由于诊断延迟。本研究旨在确定津巴布韦宫颈癌患者的风险因素、潜在预后指标和最佳治疗方式。回顾了1063例宫颈癌患者的病历，以获取社会人口统计学、临床、治疗和反应数据。所有数据均使用SPSS 25版进行分析。超过一半的队列处于绝经前（63%），宫颈癌筛查史较低（2%）。在2.4%的肿瘤标本中观察到血吸虫卵。超过50%的患者在3期及更晚期被诊断出来，合并症发生率较高（约68%）。本研究强调了在津巴布韦改善筛查教育和筛查接受率的必要性。此外，目前的数据为了解非洲人群中宫颈癌的发病机制和治疗反应提供了一个数据集。
