Cardiovascular and Applied Physiology Laboratory Florida State University Tallahassee FL.
Neurovascular Physiology Laboratory Indiana University Bloomington IN.
J Am Heart Assoc. 2024 Aug 6;13(15):e034114. doi: 10.1161/JAHA.123.034114. Epub 2024 Jul 26.
A high minute ventilation/rate of carbon dioxide production (V̇/V̇co) slope during exercise is prognostic for cardiovascular death. Recent data indicate that adults with either controlled or untreated primary hypertension, but not those with uncontrolled hypertension, exhibit a higher V̇/V̇co slope during exercise. However, the sample sizes were modest. Therefore, we used the Fitness Registry and the Importance of Exercise National Database to determine whether adults with hypertension, particularly those with controlled or untreated hypertension, exhibit higher V̇/V̇co slopes compared with adults without hypertension.
Using the Fitness Registry and the Importance of Exercise National Database, we isolated primary hypertension by excluding those with any disease other than hypertension or taking any medications other than antihypertension medications. We also excluded current smokers and those with obesity. The V̇/V̇co slope was determined during a peak cycling exercise test. All data are presented as median [interquartile range]. We compared groups using linear regression adjusted for age, male/female, and body mass index. The characteristics of the entire sample (n=4109) were age, 42 [18] years; 48% women; body mass index, 26 [4] kg/m. The V̇/V̇co slope did not differ between adults with hypertension (n=1940; 24.7 [3.7]) compared with those without hypertension (n=2169; 24.9 [3.8]) (hypertension versus no hypertension, =0.31; overall model: =0.07, F=73.0; <0.001). Further, the V̇/V̇co slope did not differ between adults with medication-controlled hypertension (n=107; 24.4 [3.0]), untreated hypertension (n=1626; 24.8 [3.9]), uncontrolled hypertension (n=207; 24.8 [3.0]), or those without hypertension (n=2169; 24.9 [3.8]) (hypertension subgroup versus no hypertension, ≥0.06; overall model: =0.07, F=49.6, <0.001).
Primary hypertension is not associated with V̇/V̇co slope in the Fitness Registry and the Importance of Exercise National Database.
运动时高分钟通气量/二氧化碳产生率（V̇/V̇co）斜率与心血管死亡相关。最近的数据表明，无论是控制良好的原发性高血压患者还是未经治疗的原发性高血压患者，其运动时的 V̇/V̇co 斜率均高于血压控制不佳的原发性高血压患者。然而，这些样本量都较小。因此，我们使用健身登记和运动重要性国家数据库来确定高血压患者，特别是控制良好或未经治疗的高血压患者，其 V̇/V̇co 斜率是否高于无高血压患者。
我们通过排除除高血压以外的任何疾病或除降压药物以外的任何药物的患者，使用健身登记和运动重要性国家数据库来确定原发性高血压。我们还排除了当前吸烟者和肥胖者。在峰值踏车运动试验期间确定了 V̇/V̇co 斜率。所有数据均以中位数[四分位距]表示。我们使用线性回归比较了年龄、男女和体重指数调整后的组间差异。整个样本（n=4109）的特征为年龄 42[18]岁；女性占 48%；体重指数 26[4]kg/m。与无高血压的患者相比，高血压患者（n=1940；24.7[3.7]）的 V̇/V̇co 斜率没有差异（高血压 vs. 无高血压，=0.31；整体模型：=0.07，F=73.0；<0.001）。此外，药物控制的高血压患者（n=107；24.4[3.0]）、未经治疗的高血压患者（n=1626；24.8[3.9]）、血压控制不佳的高血压患者（n=207；24.8[3.0]）与无高血压的患者（n=2169；24.9[3.8]）的 V̇/V̇co 斜率也没有差异（高血压亚组 vs. 无高血压，≥0.06；整体模型：=0.07，F=49.6；<0.001）。
在健身登记和运动重要性国家数据库中，原发性高血压与 V̇/V̇co 斜率无关。
