Institute of Technology, University of the National Education Commission, Krakow, ul. Podchora̧żych 2, Kraków 30-084, Poland.
Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, ul. Rokietnicka 3, Poznań 60-806, Poland.
ACS Appl Mater Interfaces. 2024 Aug 7;16(31):40714-40725. doi: 10.1021/acsami.4c08501. Epub 2024 Jul 26.
The hypothesis of the study was that (1) 3D printed drug delivery systems (DDS) could be characterized in situ during drug release using NMR/MRI techniques in terms of mass transport phenomena description (interfacial phenomena), particularly for systems dealing with two mobile phases (e.g., water and low molecular weight liquid polymer); (2) consequently, it could be possible to deduce how these interfacial mass transport phenomena influence functional properties of 3D printed DDS. Matrix drug delivery systems, prepared using masked stereolithography (MSLA), containing poly(ethylene glycol) diacrylate (PEGDA) and low molecular weight polyethylene glycol (PEG) with ropinirole hydrochloride (RH) were studied as example formulations. The PEGDA to PEG (mobile phase) concentration ratio influenced drug release. It was reflected in spatiotemporal changes in parametric T relaxation time (T) and amplitude (A) images obtained using magnetic resonance imaging (MRI) and T-T relaxation time correlations obtained using low-field time-domain nuclear magnetic resonance (LF TD NMR) relaxometry during incubation in water. For most of the tested formulations, two signal components related to PEG and water were assessed in the hydrated matrices by MRI relaxometry (parametric T/A images). The PEG component faded out due to outward PEG diffusion and was gradually replaced by the water component. Both components spatially and temporally changed their parameters, reflecting evolving water-polymer interactions. The study shows that dynamic phenomena related to bidirectional mass transport can be quantified in situ using NMR and MRI techniques to gain insight into drug release mechanisms from 3D printed DDS systems.
(1) 使用 NMR/MRI 技术，可以在药物释放过程中对 3D 打印药物输送系统 (DDS) 进行原位特性描述（界面现象），特别是针对涉及两个流动相的系统（例如水和低分子量液体聚合物）；(2) 因此，可以推断出这些界面质量传递现象如何影响 3D 打印 DDS 的功能特性。以含有盐酸罗匹尼罗 (RH) 的聚乙二醇二丙烯酸酯 (PEGDA) 和低分子量聚乙二醇 (PEG) 的掩蔽立体光刻 (MSLA) 制备的基质药物输送系统作为示例制剂进行研究。PEGDA 与 PEG（流动相）浓度比对药物释放有影响。这反映在水孵育期间使用磁共振成像 (MRI) 获得的参数 T 弛豫时间 (T) 和幅度 (A) 图像的时空变化以及使用低场时域磁共振 (LF TD NMR) 弛豫测量法获得的 T-T 弛豫时间相关性中。对于大多数测试制剂，MRI 弛豫测量法（参数 T/A 图像）评估了水合基质中与 PEG 和水相关的两个信号分量。由于 PEG 的向外扩散，PEG 分量逐渐消失，被水分量逐渐取代。两个分量在空间和时间上都改变了它们的参数，反映了不断变化的水-聚合物相互作用。该研究表明，可以使用 NMR 和 MRI 技术原位定量研究与双向质量传递相关的动态现象，以深入了解 3D 打印 DDS 系统的药物释放机制。
