De Chiara Elena, Vellone Valerio Gaetano, Ferro Jacopo, Trambaiolo Antonelli Chiara, Piro Liliana, Avanzini Stefano, Prono Valentina, Beccaria Andrea, Muraca Monica, Tallone Ramona
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal-Infantile Sciences, University of Genoa, 16126 Genoa, Italy.
Pathology Unit, IRCCS Giannina Gaslini Institute, 16147 Genoa, Italy.
Diseases. 2024 Jul 18;12(7):164. doi: 10.3390/diseases12070164.
Nerve sheath myxoma (NSM) is a rare benign peripheral nerve sheath tumor that affects young adults. NSMs are asymptomatic, slow-growing swellings located in the upper extremities, more rarely in the lower extremities. Given the high risk of recurrence, it is recommended to perform a complete exeresis. To our knowledge, the evolution and management of NMS during pregnancy have not been described yet. We report the first case of recurrent pretibial NSM in a pregnant girl and its follow-up and outcome during and after pregnancy. NSM is difficult to diagnose clinically or using imaging. The final diagnosis remains histopathological. It is known how various types of benign and malignant skin tumors can develop or change during pregnancy. With our case, however, we documented that pregnancy does not affect the growth and evolution of NSM. Given the benign nature of the lesions and their tendency to grow slowly, during pregnancy, follow-up of NSMs can be conducted through ultrasonography and surgical treatment postponed after delivery. Our case highlights the importance of careful monitoring and individualized decision making, especially in rare scenarios such as NSM, where data on the progression of benign lesions are limited. Our case highlights the importance of a careful monitoring and a tailored treatment in rare scenarios such as NSM, where data on the progression of benign lesions are limited. Considering the benign nature of the lesions and their tendency to grow slowly, follow-up of NSMs during pregnancy can be conducted through ultrasonography, and surgical treatment can be postponed after delivery.
神经鞘黏液瘤（NSM）是一种罕见的良性周围神经鞘瘤，好发于年轻人。NSM通常无症状，生长缓慢，多位于上肢，下肢较少见。鉴于其复发风险高，建议进行完整切除。据我们所知，孕期NSM的演变及处理尚未见报道。我们报告了首例怀孕女孩复发性胫前NSM及其孕期和产后的随访情况与结局。NSM在临床或影像学上都难以诊断，最终诊断仍依靠组织病理学。已知各类良性和恶性皮肤肿瘤在孕期会如何发展或变化。然而，就我们的病例而言，我们记录到孕期并不影响NSM的生长和演变。鉴于病变的良性性质及其生长缓慢的倾向，孕期NSM的随访可通过超声检查进行，手术治疗可推迟至产后。我们的病例凸显了仔细监测和个体化决策的重要性，尤其是在像NSM这样良性病变进展数据有限的罕见情况下。我们的病例凸显了在像NSM这样良性病变进展数据有限的罕见情况下进行仔细监测和量身定制治疗的重要性。考虑到病变的良性性质及其生长缓慢的倾向，孕期NSM的随访可通过超声检查进行，手术治疗可推迟至产后。
