Nozaki Y, Katayama N, Tsubotani S, Ono H, Okazaki H
J Antibiot (Tokyo). 1985 Sep;38(9):1141-51. doi: 10.7164/antibiotics.38.1141.
New 7-methoxycephem antibiotics were found in culture filtrates of a bacterium isolated from a plant and named cephabacin M1-6. They are the first members of 7-methoxycephem antibiotics of bacterial origin. The producing organism was taxonomically characterized and identified as Xanthomonas lactamgena YK-431; other strains of this species have recently been reported to produce cephabacin F and H group antibiotics. Cephabacin M1-6 exhibited moderate antibacterial activity against Gram-negative and Gram-positive bacteria. Cephabacin M1-6 were as stable as cephamycin C to cephalosporinases. They showed inhibitory activity against a cephalosporinase of Proteus vulgaris GN 4413. The mode of action of cephabacin M1 was examined using Escherichia coli and Bacillus subtilis as test organisms; primary lethal targets of cephabacin M1 are penicillin-binding protein (PBP) 1 in E. coli and PBP 4 in B. subtilis.
从一种植物中分离出的细菌的培养滤液中发现了新型7-甲氧基头孢菌素抗生素，并将其命名为头孢菌素M1-6。它们是细菌来源的7-甲氧基头孢菌素抗生素的首批成员。对产生该抗生素的生物体进行了分类学特征鉴定，确定为产内酰胺黄单胞菌YK-431；最近有报道称该物种的其他菌株可产生头孢菌素F和H组抗生素。头孢菌素M1-6对革兰氏阴性菌和革兰氏阳性菌表现出中等抗菌活性。头孢菌素M1-6与头孢西丁C对头孢菌素酶一样稳定。它们对普通变形杆菌GN 4413的头孢菌素酶表现出抑制活性。以大肠杆菌和枯草芽孢杆菌为测试生物，研究了头孢菌素M1的作用方式；头孢菌素M1的主要致死靶点是大肠杆菌中的青霉素结合蛋白（PBP）1和枯草芽孢杆菌中的PBP 4。
