Mattes J A
J Clin Psychiatry. 1985 Dec;46(12):525-7.
The literature on the use of stimulants in depression is reviewed, and a controlled study is described. Twenty mildly depressed outpatients with Hamilton Depression Rating Scale scores of 14-24 were entered into a double-blind crossover study with randomized order, comparing methylphenidate (up to 60 mg/day) and placebo. No antidepressant effect was found. A beneficial effect of stimulants in subgroups of depressed patients remains to be proven.
本文综述了关于在抑郁症中使用兴奋剂的文献，并描述了一项对照研究。20名汉密尔顿抑郁量表评分在14 - 24分的轻度抑郁门诊患者进入一项随机顺序的双盲交叉研究，比较哌甲酯（最大剂量60毫克/天）和安慰剂。未发现抗抑郁作用。兴奋剂对抑郁症患者亚组的有益作用仍有待证实。
