衰老科学与阿尔茨海默病的斗争：介于神话与现实之间。
Geroscience and the Fight Against Alzheimer's Disease: Between Myth and Reality.
机构信息
Department of Medicine and Surgery, Division of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
出版信息
J Alzheimers Dis. 2024;100(s1):S271-S276. doi: 10.3233/JAD-240582.
Aging is associated with a gradual decline in cellular stability, leading to a decrease in overall health. In the brain, this process is closely linked with an increased risk of neurodegenerative diseases, including Alzheimer's disease. Understanding the mechanisms of brain aging is crucial for developing strategies aimed at enhancing both lifespan and health span. Recent advancements in geroscience, the study of the relationship between aging and age-related diseases, have begun to redefine our understanding of Alzheimer's disease, guiding the development of preventive medical strategies that target the aging process itself rather than merely addressing the symptomatic manifestations of the disease.
衰老是与细胞稳定性的逐渐下降相关的，这会导致整体健康状况下降。在大脑中，这个过程与神经退行性疾病（包括阿尔茨海默病）的风险增加密切相关。了解大脑衰老的机制对于开发旨在延长寿命和健康寿命的策略至关重要。衰老科学的最新进展，即研究衰老与与年龄相关的疾病之间的关系，已经开始重新定义我们对阿尔茨海默病的理解，指导开发针对衰老过程本身而不是仅仅针对疾病症状的预防医学策略。
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