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罕见的合萌中毒:一例报告。

Uncommon Millettia pachycarpa Benth poisoning: A case report.

机构信息

Intensive Care Department, People's Hospital of Dafang, Bijie, China.

Intensive Care Department, West China Hospital of Sichuan University, China.

出版信息

Medicine (Baltimore). 2024 Jul 26;103(30):e38967. doi: 10.1097/MD.0000000000038967.

Abstract

BACKGROUND

Millettia pachycarpa Benth, rich in rotenone, can disrupt the mitochondrial electron transport chain. Ingestion may cause respiratory and central nervous system depression, and in severe cases, lead to death. This is the first detailed clinical case report of M. pachycarpa Benth poisoning, aiming to help systematization of diagnosis and treatment.

PATIENT CONCERNS

An elderly male who lost consciousness for 3 hours after consuming the fruit of M. pachycarpa Benth. Arterial blood gas analysis indicated a significant decrease in pH, a sharp increase in lactate levels, and elevated CO2 partial pressure with normal O2 partial pressure.

DIAGNOSIS

The patient was diagnosed with food intoxication by M. pachycarpa Benth, concomitant with aspiration pneumonia and distributive shock.

INTERVENTIONS

The patient was given continuous renal replacement therapy (CRRT) and invasive mechanical ventilation.

OUTCOMES

The patient was successfully discharged after 5 days of hospitalization. Follow-up after 2 weeks showed no significant discomfort.

CONCLUSION

Isolated CO2 retention without hypoxemia, significantly reduced pH, and markedly elevated lactate levels strongly suggest poisoning by M. pachycarpa Benth. CRRT and invasive mechanical ventilation are beneficial for patients. Early implementation of CRRT to remove toxins and early initiation of assisted ventilation to improve respiratory failure are recommended upon suspicion of the disease.

摘要

背景

密花豆(Millettia pachycarpa Benth)富含鱼藤酮,可破坏线粒体电子传递链。摄入后可能导致呼吸和中枢神经系统抑制,严重时可导致死亡。这是首例关于密花豆中毒的详细临床病例报告,旨在帮助规范化诊断和治疗。

患者关注

一名老年男性食用密花豆果实后昏迷 3 小时。动脉血气分析显示 pH 值显著降低,乳酸水平急剧升高,CO2 分压升高,而 O2 分压正常。

诊断

患者被诊断为密花豆食物中毒,同时并发吸入性肺炎和分布性休克。

干预措施

患者接受了连续肾脏替代治疗(CRRT)和有创机械通气。

结果

患者住院 5 天后成功出院。2 周后随访无明显不适。

结论

单纯性 CO2 潴留而无低氧血症、pH 值显著降低和乳酸水平显著升高强烈提示密花豆中毒。CRRT 和有创机械通气对患者有益。怀疑该病时,建议早期实施 CRRT 以清除毒素,并早期启动辅助通气以改善呼吸衰竭。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee2/11272360/dd297d6c0170/medi-103-e38967-g001.jpg

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