College of Food Science, Northeast Agricultural University, Harbin, 150030, China.
ACS Appl Mater Interfaces. 2024 Aug 7;16(31):40356-40370. doi: 10.1021/acsami.4c05106. Epub 2024 Jul 26.
Wound healing is a major challenge worldwide, and people have been researching wound dressings that can promote wound healing for decades. Natural biobased materials, such as polysaccharides and proteins, have been widely used in the development of wound dressings. Among them, soy protein-based materials have attracted the interest of a wide range of researchers due to their safety, biocompatibility, controlled degradation, and ability to be mixed with other materials. However, there has been a lack of comments on these soy protein-based wound dressings. This work reviews various forms of soy protein-based wound dressings, such as hydrogels, films, and others, which could be prepared through physical/chemical cross-linking with synthetic or natural polymers. The important role played by soy protein-based materials in the wound healing phase and their properties will be examined, such as their anti-inflammatory, antioxidant, angiogenesis-promoting, cellular biocompatibility, self-healing ability, adhesion, antimicrobial, and tunable mechanical properties. Additionally, insights into the market prospects and trends for soy protein dressings are provided, clarifying the enormous development potential of soy protein as a new type of wound repair material.
伤口愈合是一个全球性的重大挑战，人们几十年来一直在研究能够促进伤口愈合的伤口敷料。天然生物基材料，如多糖和蛋白质，已广泛应用于伤口敷料的开发中。其中，基于大豆蛋白的材料由于其安全性、生物相容性、可控降解性以及与其他材料混合的能力，引起了广泛研究人员的兴趣。然而，对于这些基于大豆蛋白的伤口敷料，缺乏相关的评论。本工作综述了各种形式的基于大豆蛋白的伤口敷料，如水凝胶、薄膜等，可以通过与合成或天然聚合物的物理/化学交联来制备。我们将考察基于大豆蛋白的材料在伤口愈合阶段所发挥的重要作用及其特性，如抗炎、抗氧化、促进血管生成、细胞生物相容性、自修复能力、附着力、抗菌和可调机械性能。此外，还提供了对大豆蛋白敷料市场前景和趋势的见解，阐明了大豆蛋白作为新型伤口修复材料的巨大发展潜力。
