Department of Pathobiology, College of Veterinary Medicine, 166 Greene Hall, Auburn University, AL, USA 36849; Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Road, North Grafton, MA, USA 01536.
IDEXX Laboratories Pty. Ltd., 20A Maui Street, Pukete, Hamilton 3200, New Zealand.
Domest Anim Endocrinol. 2024 Oct;89:106872. doi: 10.1016/j.domaniend.2024.106872. Epub 2024 Jul 9.
Fibroblast growth factors (FGFs) are a group of structurally homologous yet functionally pleiotropic proteins. Canonical and intracellular FGFs have primarily autocrine or paracrine effects. However, the FGF19 subfamily, composed of FGF15/19, FGF21, and FGF23, act as endocrine hormones that regulate bile acid, metabolic, and phosphorus homeostasis, respectively. Current research in human and rodent models demonstrates the potential of these endocrine FGFs to target various diseases, including disorders of inherited hypophosphatemia, chronic liver disease, obesity, and insulin resistance. Many diseases targeted for therapeutic use in humans have pathophysiological overlaps in domestic animals. Despite the potential clinical and economic impact, little is known about endocrine FGFs and their signaling pathways in major domestic animal species compared with humans and laboratory animals. This review aims to describe the physiology of these endocrine FGFs, discuss their current therapeutic use, and summarize the contemporary literature regarding endocrine FGFs in domestic animals, focusing on potential future directions.
成纤维细胞生长因子（FGFs）是一组结构同源但功能多样的蛋白质。经典和细胞内 FGFs 主要具有自分泌或旁分泌作用。然而，由 FGF15/19、FGF21 和 FGF23 组成的 FGF19 亚家族作为内分泌激素，分别调节胆汁酸、代谢和磷稳态。目前在人类和啮齿动物模型中的研究表明，这些内分泌 FGFs 具有靶向多种疾病的潜力，包括遗传性低磷血症、慢性肝病、肥胖症和胰岛素抵抗等疾病。许多针对人类治疗用途的疾病在宠物动物中具有生理学和病理学重叠。尽管具有潜在的临床和经济影响，但与人类和实验动物相比，人们对主要宠物动物物种中的内分泌 FGFs 及其信号通路知之甚少。本综述旨在描述这些内分泌 FGFs 的生理学，讨论它们目前的治疗用途，并总结有关宠物动物内分泌 FGFs 的当代文献，重点关注潜在的未来方向。
