嵌合抗原受体 T 细胞组合疗法治疗癌症。
CAR T cell combination therapies to treat cancer.
机构信息
Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104, USA.
Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Cancer Cell. 2024 Aug 12;42(8):1319-1325. doi: 10.1016/j.ccell.2024.07.002. Epub 2024 Jul 25.
Chimeric antigen receptor (CAR) T cells are effectively used in certain hematological malignancies, though tumor relapse and limited success in solid tumors persist. Recent efforts focus on developing combination treatments to enhance outcomes and safety. Here, we provide a comprehensive overview of such combinatorial approaches and a consideration of ongoing clinical trials.
嵌合抗原受体 (CAR) T 细胞在某些血液恶性肿瘤中得到有效应用，但肿瘤复发和实体瘤疗效有限的问题依然存在。近期的研究重点在于开发联合治疗策略，以提高疗效和安全性。本文就此类联合治疗策略进行了全面综述，并对正在进行的临床试验进行了探讨。
Zotero 插件