Sušić Tamara, Miler Marijana, Nikolac Gabaj Nora, Tešija Kuna Andrea, Kordić Krešimir, Ilić Vedrana, Vinter Ozren
Department of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
Department of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
Clin Biochem. 2024 Oct;131-132:110802. doi: 10.1016/j.clinbiochem.2024.110802. Epub 2024 Jul 24.
Elevated troponin levels are often indicative of various cardiac diseases; however, analytical interference can lead to false positive troponin concentrations. We present the case of a 48-year-old female patient with persistently falsely elevated high sensitivity troponin I (hsTnI) probably caused by the presence of macrotroponin. Laboratory testing included determination of hsTnI using various analytical methods, serial dilutions and determination of heterophilic antibodies and other autoimmune antibodies. Only precipitation with polyethylene glycol (PEG) indicated the presence of an interference by causing a significant decrease in hsTnI concentration. Our results suggest that the falsely elevated hsTnI concentration could be due to interference with the macrotroponin complex.
肌钙蛋白水平升高通常提示各种心脏疾病；然而，分析干扰可导致肌钙蛋白浓度出现假阳性。我们报告了一例48岁女性患者，其高敏肌钙蛋白I（hsTnI）持续假性升高，可能是由巨肌钙蛋白的存在所致。实验室检测包括使用各种分析方法测定hsTnI、系列稀释以及测定嗜异性抗体和其他自身抗体。仅聚乙二醇（PEG）沉淀通过导致hsTnI浓度显著降低表明存在干扰。我们的结果提示，hsTnI浓度假性升高可能是由于巨肌钙蛋白复合物的干扰。
