Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Beijing, China.
Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Sleep Center, Department of Neurology, China National Clinical Research Center of Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Neuroscience. 2024 Sep 13;555:116-124. doi: 10.1016/j.neuroscience.2024.07.025. Epub 2024 Jul 25.
Both alcohol misuse and sleep deficiency are associated with deficits in semantic processing. However, alcohol misuse and sleep deficiency are frequently comorbid and their inter-related effects on semantic processing as well as the underlying neural mechanisms remain to be investigated.
We curated the Human Connectome Project data of 973 young adults (508 women) to examine the neural correlates of semantic processing in link with the severity of alcohol use and sleep deficiency. The latter were each evaluated using the first principal component (PC1) of principal component analysis of all drinking metrics and the Pittsburgh Sleep Quality Index (PSQI). We employed path modeling to elucidate the interplay among clinical, behavioral, and neural variables.
Among women, we observed a significant negative correlation between the left precentral gyrus (PCG) and PSQI scores. Mediation analysis revealed that the left PCG activity fully mediated the relationship between PSQI scores and word comprehension in language tasks. In women alone also, the right middle frontal gyrus (MFG) exhibited a significant negative correlation with PC1. The best path model illustrated the associations among PC1, PSQI scores, PCG activity, and MFG activation during semantic processing in women.
Alcohol misuse may lead to reduced MFG activation while sleep deficiency hinder semantic processing by suppressing PCG activity in women. The pathway model underscores the influence of sleep quality and alcohol consumption severity on semantic processing in women, suggesting that sex differences in these effects need to be further investigated.
酒精滥用和睡眠不足均与语义处理缺陷有关。然而，酒精滥用和睡眠不足常常同时存在，它们对语义处理的相互影响以及潜在的神经机制仍有待研究。
我们整理了 973 名年轻成年人（508 名女性）的人类连接组计划数据，以检查与酒精使用严重程度和睡眠不足相关的语义处理的神经相关性。后两者分别使用所有饮酒指标和匹兹堡睡眠质量指数（PSQI）的主成分分析的第一主成分（PC1）进行评估。我们采用路径建模来阐明临床、行为和神经变量之间的相互作用。
在女性中，我们观察到左中央前回（PCG）与 PSQI 评分之间存在显著的负相关。中介分析表明，PCG 活性完全介导了 PSQI 评分与语言任务中单词理解之间的关系。仅在女性中，右额中回（MFG）与 PC1 也呈显著负相关。最佳路径模型说明了女性在语义处理过程中 PC1、PSQI 评分、PCG 活性和 MFG 激活之间的关联。
酒精滥用可能导致 MFG 激活减少，而睡眠不足则通过抑制女性 PCG 活性来阻碍语义处理。该路径模型强调了睡眠质量和酒精摄入严重程度对女性语义处理的影响，表明需要进一步研究这些影响在性别方面的差异。
