School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China.
Mikrochim Acta. 2024 Jul 26;191(8):485. doi: 10.1007/s00604-024-06568-x.
Rare earth (RE)-doped CaS phosphors have been widely used as light-emitting components in various fields. Nevertheless, the application of nanosized CaS particles is still significantly limited by their poor water resistance and weak luminescence. Herein, a lattice-matching strategy is developed by growing an inert shell of cubic NaYF phase on the CaS luminescent core. Due to their similarity in crystal structure, a uniform core-shell heterostructure (CaS:Ce@NaYF) can be obtained, which effectively protects the CaS:Ce core from degradation in aqueous environment and enhances its luminescence intensity. As a proof of concept, a label-free aptasensor is further constructed by combining core-shell CaS:Ce@NaYF and Au nanoparticles (AuNPs) for the ultrasensitive detection of kanamycin antibiotics. Based on the efficient FRET process, the detection linear range of kanamycin spans from 100 to 1000 nM with a detection limit of 7.8 nM. Besides, the aptasensor shows excellent selectivity towards kanamycin antibiotics, and has been successfully applied to the detection of kanamycin spiked in tap water and milk samples, demonstrating its high potential for sensing applications.
稀土（RE）掺杂的 CaS 荧光粉已广泛用作各种领域的发光元件。然而，纳米 CaS 颗粒的应用仍然受到其较差的耐水性和较弱的发光的显著限制。在此，通过在 CaS 发光核上生长立方 NaYF 相的惰性壳，开发了一种晶格匹配策略。由于它们在晶体结构上的相似性，可以获得均匀的核壳异质结构（CaS:Ce@NaYF），这有效地保护了 CaS:Ce 核免受水相环境中的降解，并增强了其发光强度。作为概念验证，通过将核壳 CaS:Ce@NaYF 和金纳米粒子（AuNPs）结合进一步构建了无标记适体传感器，用于超灵敏检测卡那霉素抗生素。基于有效的 FRET 过程，卡那霉素的检测线性范围为 100 至 1000 nM，检测限为 7.8 nM。此外，该适体传感器对卡那霉素抗生素表现出优异的选择性，并已成功应用于自来水中和牛奶样品中卡那霉素的检测，表明其在传感应用方面具有很高的潜力。
