Cagnin Silvia, Pontisso Patrizia, Martini Andrea
Department of Medicine, University of Padova, 35123 Padova, Italy.
Cancers (Basel). 2024 Jul 18;16(14):2579. doi: 10.3390/cancers16142579.
SerpinB3, a member of the serine-protease inhibitor family, has emerged as a crucial player in various physiological and pathological processes. Initially identified as an oncogenic factor in squamous cell carcinomas, SerpinB3's intricate involvement extends from fibrosis progression and cancer to cell protection in acute oxidative stress conditions. This review explores the multifaceted roles of SerpinB3, focusing on its implications in fibrosis, metabolic syndrome, carcinogenesis and immune system impairment. Furthermore, its involvement in tissue protection from oxidative stress and wound healing underscores its potential as diagnostic and therapeutic tool. Recent studies have described the therapeutic potential of targeting SerpinB3 through its upstream regulators, offering novel strategies for cancer treatment development. Overall, this review underscores the importance of further research to fully elucidate the mechanisms of action of SerpinB3 and to exploit its therapeutic potential across various medical conditions.
丝氨酸蛋白酶抑制剂家族成员SerpinB3已成为各种生理和病理过程中的关键参与者。SerpinB3最初被鉴定为鳞状细胞癌中的致癌因子，其复杂的作用范围从纤维化进展、癌症到急性氧化应激条件下的细胞保护。本文综述探讨了SerpinB3的多方面作用，重点关注其在纤维化、代谢综合征、致癌作用和免疫系统损伤中的意义。此外，它在组织抗氧化应激和伤口愈合中的作用突出了其作为诊断和治疗工具的潜力。最近的研究描述了通过其上游调节因子靶向SerpinB3的治疗潜力，为癌症治疗开发提供了新策略。总体而言，本文综述强调了进一步研究以充分阐明SerpinB3作用机制并在各种医学病症中发挥其治疗潜力的重要性。
