Amiriantz Sophie, Hoummady Sara, Jarousse Elodie, Roudeix Séverine, Philippon Thomas
Dômes Pharma, ZA Champ Lamet, 3 Rue André Citroën, 63430 Pont-du-Château, France.
Transformations et Agro-Ressources, ULR 7519, Institut Polytechnique Unilasalle-Collège Vétérinaire, Université d'Artois, 76130 Mont Saint Aignan, France.
Antibiotics (Basel). 2024 Jun 30;13(7):611. doi: 10.3390/antibiotics13070611.
In the current context of emerging and spreading antimicrobial resistance in human and animal infections, new strategies need to be developed to improve the efficacy of commonly prescribed antibiotics and preserve more critical compounds for multi-drug-resistant infections. This preliminary study aimed at evaluating the benefits of an eye cleaning solution containing 0.1% EDTA, 0.02% Tris, and 0.1% Polysorbate 80 in veterinary ophthalmology. A first in vitro study was performed to assess the bactericidal activity of the test solution against and strains. A second in vitro study evaluated the impact of the test solution on the antimicrobial activity of neomycin against . The test solution alone did not show bactericidal activity against and . The test solution seemed to increase the activity of Neomycin Sulfate against . These findings warrant further research to better characterize the impact on the bactericidal activity of antimicrobials used in veterinary ocular surface infections of the solution containing 0.1% EDTA, 0.02% Tris, and 0.1% Polysorbate 80 as well as of each individual ingredient for a thorough understanding of how this test solution could provide a new strategy to address the growing antimicrobial resistance issue worldwide.
在当前人类和动物感染中抗菌药物耐药性不断出现和传播的背景下，需要制定新策略来提高常用抗生素的疗效，并为多重耐药感染保留更关键的药物。这项初步研究旨在评估一种含有0.1%乙二胺四乙酸（EDTA）、0.02%三羟甲基氨基甲烷（Tris）和0.1%聚山梨酯80的眼部清洁溶液在兽医眼科学中的益处。进行了第一项体外研究，以评估测试溶液对[具体菌株1]和[具体菌株2]菌株的杀菌活性。第二项体外研究评估了测试溶液对新霉素针对[具体菌株3]的抗菌活性的影响。单独的测试溶液对[具体菌株1]和[具体菌株2]未显示出杀菌活性。测试溶液似乎增加了硫酸新霉素对[具体菌株3]的活性。这些发现值得进一步研究，以更好地描述含有0.1% EDTA、0.02% Tris和0.1%聚山梨酯80的溶液以及每种单独成分对兽医眼表感染中使用的抗菌药物杀菌活性的影响，从而全面了解该测试溶液如何能够提供一种新策略来解决全球日益严重的抗菌药物耐药性问题。
