Liu Qi, Zhang Yumei
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Department of Rehabilitation, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Brain Sci. 2024 Jul 3;14(7):676. doi: 10.3390/brainsci14070676.
This study aims to understand the cognitive profiles of cerebellar infarction patients and compare them to those with supratentorial infarctions, particularly frontal infarctions. This current study also aims to find reliable assessment tools for detecting cognitive impairment in cerebellar infarction patients. A total of fifty cerebellar infarction patients, sixty supratentorial infarction patients, and thirty-nine healthy controls were recruited. The Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Addenbrooke's Cognitive Examination III (ACE-III), and Cerebellar Cognitive Affective Syndrome scale (CCAS-s) were used to assess global cognitive function. An extensive neuropsychological assessment battery was also tested to evaluate the characteristics of each cognitive domain. To assess the features of cognitive function, a comprehensive neuropsychological evaluation tool was also utilized. The cerebral infarction patients demonstrated cognitive impairment comparable to those with frontal infarcts, notably characterized by disturbance in attention and executive function. However, the degree of cognitive impairment was comparatively milder in cerebellar infarction patients. Furthermore, the patients in the cerebellar group had worse scores in the ACE-III and CCAS-s compared to healthy controls. The two assessments also demonstrated a significant area under the curve values, indicating their effectiveness in distinguishing cognitive impairment in cerebellar infarctions. In conclusion, cognitive impairment in a cerebellar infarction resembles frontal lobe dysfunction but is generally mild. It can be accurately assessed using the ACE-III and CCAS-s scales.
本研究旨在了解小脑梗死患者的认知特征，并将其与幕上梗死患者，特别是额叶梗死患者进行比较。本研究还旨在找到可靠的评估工具来检测小脑梗死患者的认知障碍。共招募了50例小脑梗死患者、60例幕上梗死患者和39名健康对照者。使用简易精神状态检查表（MMSE）、蒙特利尔认知评估量表（MoCA）、Addenbrooke认知检查表第三版（ACE-III）和小脑认知情感综合征量表（CCAS-s）来评估整体认知功能。还测试了一套广泛的神经心理学评估量表，以评估每个认知领域的特征。为了评估认知功能的特点，还使用了一种综合神经心理学评估工具。脑梗死患者表现出与额叶梗死患者相当的认知障碍，其显著特征是注意力和执行功能紊乱。然而，小脑梗死患者的认知障碍程度相对较轻。此外，与健康对照者相比，小脑组患者在ACE-III和CCAS-s量表上的得分更低。这两项评估还显示出显著的曲线下面积值，表明它们在区分小脑梗死认知障碍方面的有效性。总之，小脑梗死中的认知障碍类似于额叶功能障碍，但一般较轻。使用ACE-III和CCAS-s量表可以准确评估。
