Baran Gozde, Yildiz Suleyman Sezai, Oner Ozge Gonul, Gurdal Ahmet, Keskin Kudret, Sigirci Serhat, Orta Kilickesmez Kadriye, Babacan Yildiz Gulsen
Department of Neurology, Sancaktepe Sehit Prof. Dr. Ilhan Varank Research and Training Hospital, 34785 Istanbul, Turkey.
Department of Cardiology, University of Health Sciences, SBÜ Prof. Dr. Cemil Tascioglu City Hospital, 34384 Istanbul, Turkey.
Diagnostics (Basel). 2024 Jul 11;14(14):1492. doi: 10.3390/diagnostics14141492.
It is not clear whether cognitive functions are impaired in young patients with acute coronary syndrome (ACS). This study aims to detect whether or not there is cognitive impairment and cerebral changes in young patients with ACS undergoing percutaneous coronary intervention (PCI).
All 50 patients with ACS who were treated with primary PCI were eligible for this prospective study. All participants had normal cognitive function before ACS. Brain magnetic resonance imaging (MRI) was performed to quantify changes in brain white and gray matter. Cognitive functions (CFs) were evaluated by seven cognitive tests. Patients were categorized by MRI findings and test scores were compared from the first day to after the first month.
We determined 25 patients with impaired CFs on the first day. After the first month, we identified 18 patients with transient impaired CFs. No structural difference was observed between impaired CF and normal CF. While 25 patients had a score of 1 according to Fazekas, 10 patients had a score of 1 according to MTLA. While the mean Stroop test completion time and Stroop test error rate scores were significantly higher on the first day than after the first month in the Fazekas+ group ( = 0.003, < 0.001, respectively), other cognitive test scores-except clock drawing test, digital span forwards, and backwards-were significantly lower on the first day compared to after the first month in the Fazekas+ group ( < 0.05).
Patients with ACS have transient impairment in cognitive functions. Acute coronary syndrome is not associated with structural changes in the brain.
急性冠状动脉综合征（ACS）年轻患者的认知功能是否受损尚不清楚。本研究旨在检测接受经皮冠状动脉介入治疗（PCI）的ACS年轻患者是否存在认知障碍和脑部变化。
所有50例接受直接PCI治疗的ACS患者均符合本前瞻性研究的条件。所有参与者在发生ACS之前认知功能均正常。进行脑磁共振成像（MRI）以量化脑白质和灰质的变化。通过七项认知测试评估认知功能（CFs）。根据MRI结果对患者进行分类，并比较从第一天到第一个月后的测试分数。
我们确定第一天有25例CFs受损的患者。第一个月后，我们发现18例患者存在短暂的CFs受损。受损CF和正常CF之间未观察到结构差异。根据法泽卡斯量表，25例患者评分为1分，根据改良蒙特利尔认知评估量表（MTLA），10例患者评分为1分。在法泽卡斯量表评分为1分的组中，第一天的平均斯特鲁普测试完成时间和斯特鲁普测试错误率得分显著高于第一个月后（分别为P = 0.003，P < 0.001），与第一个月后相比，该组第一天的其他认知测试分数（除画钟试验、数字顺背和倒背外）显著更低（P < 0.05）。
ACS患者存在认知功能的短暂损害。急性冠状动脉综合征与脑部结构变化无关。
