Gorsline J, Morris D J
J Steroid Biochem. 1985 Oct;23(4):535-6. doi: 10.1016/0022-4731(85)90204-3.
Infusions of 10 or 25 micrograms/day 19-nor-DOC for 2 weeks in adrenalectomized spontaneously hypertensive rats led to significant increases in blood pressure, 55 and 70 mmHg respectively. This study provides further evidence that 19-nor-DOC is a potent hypertensinogenic steroid and that the ADX SHR model is a useful, sensitive bioassay system to test for hypertensinogenic activity.
对肾上腺切除的自发性高血压大鼠连续2周每天输注10或25微克的19-去甲脱氧皮质酮，导致血压显著升高，分别升高了55和70毫米汞柱。本研究进一步证明，19-去甲脱氧皮质酮是一种强效的致高血压类固醇，并且肾上腺切除的自发性高血压大鼠模型是一种用于检测致高血压活性的有用且敏感的生物测定系统。
