Miedema F, Tromp J F, van't Veer M B, Poppema S, Melief C J
Leuk Res. 1985;9(9):1099-104. doi: 10.1016/0145-2126(85)90098-0.
Lymphocyte function-associated antigen 1 (LFA-1) is a membrane glycoprotein involved in a wide variety of functional activities mediated by human leukocytes. For example, expression of LFA-1 is required on immunoregulatory lymphocytes for functional activity. The appearance of LFA-1 in lymphocyte ontogeny was studied using leukemic cells as probes of distinct maturation stages. LFA-1 was expressed on the neoplastic cells of all mature T-cell neoplasias including T-prolymphocytic leukemia cells but not on immature T-cell blasts in acute lymphoblastic leukemia. The expanded T gamma-cell population in T gamma-lymphocytosis patients expressed very high amounts of LFA-1 compared to normal T cells. The malignant cells in B-chronic lymphocytic leukemia and common acute lymphoblastic leukemia were negative in all cases tested except one. In all B-prolymphocytic leukemia's and some of the B-Non Hodgkin's lymphoma patients the neoplastic cells expressed LFA-1. The plasma cells in two patients with plasmacytoma were found to lack LFA-1. It is concluded that LFA-1 is expressed on mature immunocompetent lymphocytes and their neoplastic counterparts.
淋巴细胞功能相关抗原1（LFA-1）是一种膜糖蛋白，参与人类白细胞介导的多种功能活动。例如，免疫调节淋巴细胞发挥功能活性需要表达LFA-1。利用白血病细胞作为不同成熟阶段的探针，研究了LFA-1在淋巴细胞个体发育中的出现情况。LFA-1在所有成熟T细胞肿瘤的肿瘤细胞上表达，包括T原淋巴细胞白血病细胞，但在急性淋巴细胞白血病的未成熟T细胞母细胞上不表达。与正常T细胞相比，Tγ淋巴细胞增多症患者中扩增的Tγ细胞群体表达非常高的LFA-1。除1例测试病例外，B慢性淋巴细胞白血病和常见急性淋巴细胞白血病的恶性细胞在所有测试病例中均为阴性。在所有B原淋巴细胞白血病患者和一些B非霍奇金淋巴瘤患者中，肿瘤细胞表达LFA-1。发现两名浆细胞瘤患者的浆细胞缺乏LFA-1。得出的结论是，LFA-1在成熟的免疫活性淋巴细胞及其肿瘤对应物上表达。
