维生素D的生理学与病理生理学

The physiology and pathophysiology of vitamin D.

作者信息

Audran M, Kumar R

出版信息

Mayo Clin Proc. 1985 Dec;60(12):851-66. doi: 10.1016/s0025-6196(12)64791-0.

Abstract

The vitamin D endocrine system plays an important role in the maintenance of normal calcium homeostasis. Abnormalities of this system occur in many conditions, such as rickets, osteomalacia, hypoparathyroidism, and hyperparathyroidism. The diagnosis and treatment of these disorders will be facilitated if the clinician understands the general mechanisms by which defects in vitamin D metabolism and action occur. We review this information and discuss the use and limitations of vitamin D metabolite assays for diagnosis of clinical disorders of mineral metabolism.

摘要

维生素D内分泌系统在维持正常钙稳态中起重要作用。该系统的异常发生于许多病症中，如佝偻病、骨软化症、甲状旁腺功能减退症和甲状旁腺功能亢进症。如果临床医生了解维生素D代谢和作用缺陷发生的一般机制，将有助于这些疾病的诊断和治疗。我们回顾这些信息，并讨论维生素D代谢物检测在矿物质代谢临床疾病诊断中的应用及局限性。