Department of Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Int J Mol Sci. 2024 Jul 21;25(14):7962. doi: 10.3390/ijms25147962.
Previous studies have revealed the medicinal and therapeutic effects of . However, no studies have focused on the antihypertensive effects of . Therefore, we aimed to determine the vasorelaxant and hypotensive effects of 50% ethanolic extract (GCE). To evaluate the vascular relaxing effect of GCE, experiments were conducted using aortic segments dissected from Sprague Dawley rats. GCE showed a vasorelaxant effect via the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway, inhibiting Ca channels, and activating K channels. The hypotensive effects of GCE were evaluated in spontaneously hypertensive rats (SHRs). The SHRs were randomly divided into a control group and orally administered GCE group (100 or 300 mg/kg). The systolic and diastolic blood pressure decreased significantly by -19.47 ± 4.58% and -31.14 ± 7.66% in the GCE 100 mg/kg group, and -21.64 ± 2.40% and -31.91 ± 5.75% in the GCE 300 mg/kg group at 4 h after administration. Considering its vasorelaxant and hypotensive effects, our results indicate that GCE may be a valuable solution for the control of hypertension. However, further studies on the long-term administration and toxicity of GCE are required.
先前的研究已经揭示了 的药用和治疗功效。然而，目前还没有研究集中于 的降压作用。因此，我们旨在确定 50%乙醇提取物（GCE）的血管舒张和降压作用。为了评估 GCE 的血管舒张作用，使用从 Sprague Dawley 大鼠分离的主动脉段进行了实验。GCE 通过一氧化氮/环鸟苷酸 3'，5'-单磷酸途径、抑制钙通道和激活钾通道表现出血管舒张作用。在自发性高血压大鼠（SHR）中评估了 GCE 的降压作用。SHR 被随机分为对照组和口服 GCE 组（100 或 300 mg/kg）。GCE 100 mg/kg 组的收缩压和舒张压分别显著下降了-19.47±4.58%和-31.14±7.66%，GCE 300 mg/kg 组分别下降了-21.64±2.40%和-31.91±5.75%，在给药后 4 小时。考虑到其血管舒张和降压作用，我们的结果表明 GCE 可能是控制高血压的一种有价值的方法。然而，需要进一步研究 GCE 的长期给药和毒性。
Zotero 插件
