Shin Sujin, Park Junkyu, Choi Ho-Young, Bu Youngmin, Lee Kyungjin
Department of Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Biomedicines. 2024 Feb 1;12(2):346. doi: 10.3390/biomedicines12020346.
Natural compounds, known for diverse pharmacological properties, have attracted attention as potential sources for hypertension treatment. Previous studies have revealed the hypotensive effect and vascular relaxation of prunetin, a natural compound derived from . However, the potential blood pressure-lowering and vasorelaxant effects of sakuranetin, another representative compound found in plants belonging to the genus , have remained unexplored. We aimed to fill this gap by investigating the hypotensive and vasorelaxant effects of sakuranetin in rats. Results indicated that sakuranetin, particularly in the sakuranetin 20 mg/kg group, led to significant reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) by -14.53 ± 5.64% and -19.83 ± 6.56% at 4 h after administration. In the sakuranetin 50 mg/kg group, the SBP and DBP decreased by -13.27 ± 6.86% and -16.62 ± 10.01% at 2 h and by -21.61 ± 4.49% and -30.45 ± 5.21% at 4 h after administration. In addition, we identified the vasorelaxant effects of sakuranetin, attributing its mechanisms to the inhibition of calcium influx and the modulation of angiotensin II. Considering its hypotensive and vasorelaxant effects, sakuranetin could potentially serve as an antihypertensive agent. However, further research is required to evaluate the safety and long-term efficacy.
天然化合物因其多样的药理特性而备受关注，成为高血压治疗潜在的药物来源。先前的研究已经揭示了柚皮素（一种天然化合物）的降压作用和血管舒张作用。然而，樱花素（在某属植物中发现的另一种代表性化合物）潜在的降压和血管舒张作用尚未得到研究。我们旨在通过研究樱花素对大鼠的降压和血管舒张作用来填补这一空白。结果表明，樱花素，特别是在樱花素20mg/kg组，给药后4小时收缩压（SBP）和舒张压（DBP）显著降低，分别降低了-14.53±5.64%和-19.83±6.56%。在樱花素50mg/kg组，给药后2小时SBP和DBP分别降低了-13.27±6.86%和-16.62±10.01%，给药后4小时分别降低了-21.61±4.49%和-30.45±5.21%。此外，我们确定了樱花素的血管舒张作用，其机制归因于抑制钙内流和调节血管紧张素II。鉴于其降压和血管舒张作用，樱花素可能成为一种抗高血压药物。然而，需要进一步研究来评估其安全性和长期疗效。
