Tian Mengxiang, Zhang Shuai, Tan Fengbo
Department of General Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410017, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410017, China.
J Pers Med. 2024 Jul 9;14(7):736. doi: 10.3390/jpm14070736.
Gastric cancer ranks among the top five deadliest tumors worldwide, both in terms of prevalence and mortality rates. Despite mainstream treatments, the efficacy in treating gastric cancer remains suboptimal, underscoring the urgency for novel therapeutic approaches. The elucidation of tumor immunosuppressive microenvironments has shifted focus towards cancer biotherapeutics, which leverage the patient's immune system or biologics to target tumor cells. Biotherapy has emerged as a promising alternative for tumors resistant to traditional chemotherapy, radiation, and immunotherapy. Central to this paradigm is the cGAS-STING pathway, a pivotal component of the innate immune system. This pathway recognizes aberrant DNA, such as that from viral infections or tumor cells, and triggers an immune response, thereby reshaping the immunosuppressive tumor microenvironment into an immune-stimulating milieu. In the context of gastric cancer, harnessing the cGAS-STING pathway holds significant potential for biotherapeutic interventions. This review provides a comprehensive overview of the latest research on cGAS-STING in gastric cancer, including insights from clinical trials involving STING agonists. Furthermore, it assesses the prospects of targeting the cGAS-STING pathway as a novel biotherapeutic strategy for gastric cancer.
无论从发病率还是死亡率来看，胃癌都是全球最致命的五大肿瘤之一。尽管有主流治疗方法，但胃癌的治疗效果仍不尽人意，凸显了新型治疗方法的紧迫性。肿瘤免疫抑制微环境的阐明使人们将重点转向癌症生物疗法，即利用患者的免疫系统或生物制剂来靶向肿瘤细胞。生物疗法已成为对传统化疗、放疗和免疫疗法耐药的肿瘤的一种有前景的替代方法。这一模式的核心是cGAS-STING通路，它是固有免疫系统的关键组成部分。该通路识别异常DNA，如来自病毒感染或肿瘤细胞的DNA，并触发免疫反应，从而将免疫抑制性肿瘤微环境重塑为免疫刺激性环境。在胃癌的背景下，利用cGAS-STING通路进行生物治疗干预具有巨大潜力。本综述全面概述了胃癌中cGAS-STING的最新研究，包括涉及STING激动剂的临床试验的见解。此外，它还评估了靶向cGAS-STING通路作为胃癌新型生物治疗策略的前景。
