Lippera Myrta, Moussa George, Ivanova Tsveta, Ferrara Mariantonia, Spiess Karina, Ally Naseer, Jasani Kirti, Dhawahir-Scala Felipe, Patton Niall, Jalil Assad
Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WL, UK.
School of Medicine, University of Malaga, 29071 Malaga, Spain.
J Pers Med. 2024 Jul 16;14(7):755. doi: 10.3390/jpm14070755.
We investigate novel OCT parameters, based on the volumetric analysis of lamellar macular holes (LMHs), as prognostic indicators for visual outcomes after surgery.
LMHs were divided into degenerative LMHs (D-LMHs) and ERM-foveoschisis (ERM-FS). Pre-operative clinical, OCT linear and volumetric parameters were collected. Volumes were obtained using the OCT automatic segmentation, such as central retinal volume (CRV) and outer nuclear layer (ONL) volume, or using a novel method to calculate volumes of specific LMH entities like epiretinal proliferation (ERP), foveal cavity (FC) in D-LMH and schitic volume (SV) in ERM-FS. Univariate and multivariate linear regression analysis evaluated the factors predictive for post-operative best-corrected visual acuity (BCVA).
We included 31 eyes of 31 patients (14 D-LMH,17 ERM-FS). A pre-operative BCVA ≤ 0.48 logMAR was a predictor for achieving ≤0.30 logMAR at final follow-up. A lower pre-operative BCVA ( = 0.008) and the presence of ERP ( = 0.002) were associated with worse visual outcomes post-surgery. Moreover, novel pre-operative OCT parameters significantly associated with worse post-operative BCVA, such as increased FC volume ( = 0.032) and lower CRV ( = 0.034) in the D-LMH subtype and lower CRV ( < 0.001) and ERP volume ( < 0.001), higher SV ( < 0.001) and foveal ONL volume ( < 0.001) in the ERM-FS subtype.
Novel volumetric OCT parameters can be prognostic indicators of visual outcome following surgery in LMHs.
我们基于黄斑板层裂孔（LMH）的容积分析研究新的光学相干断层扫描（OCT）参数，作为手术后视力预后指标。
将LMH分为变性性LMH（D-LMH）和视网膜前膜性黄斑劈裂（ERM-FS）。收集术前临床、OCT线性和容积参数。使用OCT自动分割获取容积，如中央视网膜容积（CRV）和外核层（ONL）容积，或使用一种新方法计算特定LMH实体的容积，如视网膜前增殖（ERP）、D-LMH中的黄斑裂腔（FC）以及ERM-FS中的劈裂容积（SV）。单因素和多因素线性回归分析评估预测术后最佳矫正视力（BCVA）的因素。
我们纳入了31例患者的31只眼（14例D-LMH，17例ERM-FS）。术前BCVA≤0.48 logMAR是最终随访时达到≤0.30 logMAR的预测指标。术前BCVA较低（P = 0.008）和存在ERP（P = 0.002）与术后视力较差相关。此外，术前新的OCT参数与术后较差的BCVA显著相关，如D-LMH亚型中FC容积增加（P = 0.032）和CRV降低（P = 0.034），以及ERM-FS亚型中CRV降低（P < 0.001）、ERP容积降低（P < 0.001）、SV增加（P < 0.001）和黄斑ONL容积增加（P < 0.001）。
新的OCT容积参数可作为LMH手术后视力预后的指标。
