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菜豆毒素：其合成所涉及的环境条件及调控机制

Phaseolotoxin: Environmental Conditions and Regulatory Mechanisms Involved in Its Synthesis.

作者信息

Arvizu-Gómez Jackeline Lizzeta, Hernández-Morales Alejandro, Campos-Guillén Juan, González-Reyes Christian, Pacheco-Aguilar Juan Ramiro

机构信息

Secretaría de Investigación y Posgrado, Centro Nayarita de Innovación y Transferencia de Tecnología (CENITT), Universidad Autónoma de Nayarit, Tepic 63000, Mexico.

Facultad de Estudios Profesionales Zona Huasteca, Universidad Autónoma de San Luis Potosí, Ciudad Valles 79060, Mexico.

出版信息

Microorganisms. 2024 Jun 26;12(7):1300. doi: 10.3390/microorganisms12071300.

DOI:10.3390/microorganisms12071300
PMID:39065068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11278893/
Abstract

Phaseolotoxin is an antimetabolite toxin produced by diverse pathovars of Pseudomonas syringae which affects various plants, causing diseases of economic importance. Phaseolotoxin contributes to the systemic dissemination of the pathogen in the plant, therefore it is recognized as a major virulence factor. Genetic traits such as the Pht cluster, appear defining to the toxigenic strains phaseolotoxin producers. Extensive research has contributed to our knowledge concerning the regulation of phaseolotoxin revealing a complex regulatory network that involves processes at the transcriptional and posttranscriptional levels, in which specific and global regulators participate. Even more, significant advances in understanding how specific signals, including host metabolites, nutrient sources, and physical parameters such as the temperature, can affect phaseolotoxin production have been made. A general overview of the phaseolotoxin regulation, focusing on the chemical and physical cues, and regulatory pathways involved in the expression of this major virulence factor will be given in the present work.

摘要

菜豆毒素是丁香假单胞菌不同致病型产生的一种抗代谢毒素，它会影响多种植物，引发具有经济重要性的病害。菜豆毒素有助于病原体在植物体内的系统传播，因此被认为是一种主要的毒力因子。诸如Pht基因簇等遗传特征似乎对产菜豆毒素的致病菌株具有决定性作用。广泛的研究增进了我们对菜豆毒素调控的了解，揭示了一个复杂的调控网络，该网络涉及转录和转录后水平的过程，其中特定和全局调节因子都参与其中。此外，在理解包括宿主代谢物、营养源以及温度等物理参数在内的特定信号如何影响菜豆毒素产生方面也取得了重大进展。本研究将对菜豆毒素的调控进行概述，重点关注涉及这种主要毒力因子表达的化学和物理线索以及调控途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7492/11278893/abfd0cd87da7/microorganisms-12-01300-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7492/11278893/ee1b165023ea/microorganisms-12-01300-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7492/11278893/a88d4934ad49/microorganisms-12-01300-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7492/11278893/a24949a6c009/microorganisms-12-01300-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7492/11278893/abfd0cd87da7/microorganisms-12-01300-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7492/11278893/ee1b165023ea/microorganisms-12-01300-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7492/11278893/a88d4934ad49/microorganisms-12-01300-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7492/11278893/a24949a6c009/microorganisms-12-01300-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7492/11278893/abfd0cd87da7/microorganisms-12-01300-g004.jpg

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OxyR Positively Influences Phaseolotoxin Synthesis and Pyoverdin Production in pv. NPS3121.OxyR对菜豆致病变种NPS3121中菜豆毒素的合成和绿脓菌素的产生具有正向影响。
Microorganisms. 2022 Oct 27;10(11):2123. doi: 10.3390/microorganisms10112123.
2
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Toxins (Basel). 2021 Sep 7;13(9):628. doi: 10.3390/toxins13090628.
3
Two Homologues of the Global Regulator Csr/Rsm Redundantly Control Phaseolotoxin Biosynthesis and Virulence in the Plant Pathogen pv. phaseolicola 1448A.
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Microorganisms. 2020 Oct 6;8(10):1536. doi: 10.3390/microorganisms8101536.
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Phytotoxin synthesis genes and type III effector genes of pv. biovar 6 are regulated by culture conditions.丁香假单胞菌生物变种6的植物毒素合成基因和III型效应子基因受培养条件调控。
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