• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种用于触发伏立康唑递送以有效治疗肺曲霉病的新型可吸入干粉。

A Novel Inhalable Dry Powder to Trigger Delivery of Voriconazole for Effective Management of Pulmonary Aspergillosis.

作者信息

Almurshedi Alanood S, Almarshad Sarah N, Bukhari Sarah I, Aldosari Basmah N, Alhabardi Samiah A, Alkathiri Fai A, Saleem Imran, Aldosar Noura S, Zaki Randa Mohammed

机构信息

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.

出版信息

Pharmaceutics. 2024 Jul 4;16(7):897. doi: 10.3390/pharmaceutics16070897.

DOI:10.3390/pharmaceutics16070897
PMID:39065594
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11280232/
Abstract

Invasive pulmonary aspergillosis (IPA) is a fatal fungal infection with a high mortality rate. Voriconazole (VCZ) is considered a first-line therapy for IPA and shows efficacy in patients for whom other antifungal treatments have been unsuccessful. The objective of this study was to develop a high-potency VCZ-loaded liposomal system in the form of a dry-powder inhaler (DPI) using the spray-drying technique to convert liposomes into a nanocomposite microparticle (NCMP) DPI, formulated using a thin-film hydration technique. The physicochemical properties, including size, morphology, entrapment efficiency, and loading efficiency, of the formulated liposomes were evaluated. The NCMPs were then examined to determine their drug content, production yield, and aerodynamic size. The L3NCMP was formulated using a 1:1 lipid/L-leucine ratio and was selected for in vitro studies of cell viability, antifungal activity, and stability. These formulated inhalable particles offer a promising approach to the effective management of IPA.

摘要

侵袭性肺曲霉病（IPA）是一种死亡率很高的致命真菌感染。伏立康唑（VCZ）被认为是IPA的一线治疗药物，对其他抗真菌治疗无效的患者显示出疗效。本研究的目的是利用喷雾干燥技术开发一种高效的载VCZ脂质体系统，制成干粉吸入器（DPI），将脂质体转化为纳米复合微粒（NCMP）DPI，采用薄膜水化技术进行配制。对所制备脂质体的物理化学性质，包括大小、形态、包封率和载药率进行了评估。然后对NCMP进行检查，以确定其药物含量、产率和空气动力学尺寸。使用1:1的脂质/L-亮氨酸比例配制L3NCMP，并选择其进行细胞活力、抗真菌活性和稳定性的体外研究。这些制备的可吸入颗粒为IPA的有效管理提供了一种有前景的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/5f27291cf887/pharmaceutics-16-00897-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/783daf5a23ee/pharmaceutics-16-00897-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/06a9fca5d1d1/pharmaceutics-16-00897-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/5bb2164642ac/pharmaceutics-16-00897-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/733f6f2168e1/pharmaceutics-16-00897-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/540911743190/pharmaceutics-16-00897-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/70ac124581df/pharmaceutics-16-00897-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/5f27291cf887/pharmaceutics-16-00897-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/783daf5a23ee/pharmaceutics-16-00897-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/06a9fca5d1d1/pharmaceutics-16-00897-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/5bb2164642ac/pharmaceutics-16-00897-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/733f6f2168e1/pharmaceutics-16-00897-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/540911743190/pharmaceutics-16-00897-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/70ac124581df/pharmaceutics-16-00897-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb49/11280232/5f27291cf887/pharmaceutics-16-00897-g007.jpg

相似文献

1
A Novel Inhalable Dry Powder to Trigger Delivery of Voriconazole for Effective Management of Pulmonary Aspergillosis.一种用于触发伏立康唑递送以有效治疗肺曲霉病的新型可吸入干粉。
Pharmaceutics. 2024 Jul 4;16(7):897. doi: 10.3390/pharmaceutics16070897.
2
Inhalable liposomal dry powder of gemcitabine-HCl: Formulation, in vitro characterization and in vivo studies.盐酸吉西他滨吸入性脂质体干粉的制备：制剂、体外特性及体内研究。
Int J Pharm. 2015 Dec 30;496(2):886-95. doi: 10.1016/j.ijpharm.2015.10.020. Epub 2015 Oct 21.
3
Enhanced Aerosolization of High Potency Nanoaggregates of Voriconazole by Dry Powder Inhalation.高浓度伏立康唑纳米聚集体干粉吸入剂的气溶胶化增强作用。
Mol Pharm. 2019 May 6;16(5):1799-1812. doi: 10.1021/acs.molpharmaceut.8b00907. Epub 2019 Apr 10.
4
Pulmonary delivery of liposomal dry powder inhaler formulation for effective treatment of idiopathic pulmonary fibrosis.用于有效治疗特发性肺纤维化的脂质体干粉吸入剂配方的肺部给药
Asian J Pharm Sci. 2018 Jan;13(1):91-100. doi: 10.1016/j.ajps.2017.08.005. Epub 2017 Aug 18.
5
Highly respirable dry powder inhalable formulation of voriconazole with enhanced pulmonary bioavailability.伏立康唑的高可吸入性干粉吸入制剂，具有增强的肺部生物利用度。
Expert Opin Drug Deliv. 2016;13(2):183-93. doi: 10.1517/17425247.2016.1114603. Epub 2015 Nov 26.
6
Development of an inhaled controlled release voriconazole dry powder formulation for the treatment of respiratory fungal infection.开发用于治疗呼吸道真菌感染的吸入型控释伏立康唑干粉制剂。
Mol Pharm. 2015 Jun 1;12(6):2001-9. doi: 10.1021/mp500808t. Epub 2015 May 7.
7
Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition.通过喷雾冷冻干燥制备具有高效肺部沉积的多孔、高分散性伏立康唑干粉用于肺部给药。
Int J Pharm. 2019 Apr 5;560:144-154. doi: 10.1016/j.ijpharm.2019.01.057. Epub 2019 Feb 4.
8
Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary arterial hypertension.新型可吸入西地那非枸橼酸盐喷雾干燥微球的设计与评价：用于肺动脉高压。
J Control Release. 2019 May 28;302:126-139. doi: 10.1016/j.jconrel.2019.03.029. Epub 2019 Mar 30.
9
Dry powder insufflation of crystalline and amorphous voriconazole formulations produced by thin film freezing to mice.采用薄膜冷冻法将结晶型和无定形伏立康唑制剂制成干粉，对小鼠进行干粉吸入给药。
Eur J Pharm Biopharm. 2012 Aug;81(3):600-8. doi: 10.1016/j.ejpb.2012.04.019. Epub 2012 May 1.
10
Effect of formulation and inhaler parameters on the dispersion of spray freeze dried voriconazole particles.制剂和吸入器参数对喷雾冷冻干燥伏立康唑颗粒分散性的影响。
Int J Pharm. 2020 Jun 30;584:119444. doi: 10.1016/j.ijpharm.2020.119444. Epub 2020 May 21.

引用本文的文献

1
Poloxamer 188 stabilized poly (ε-caprolactone) microspheres of voriconazole for targeting pulmonary aspergillosis.泊洛沙姆188稳定的伏立康唑聚（ε-己内酯）微球用于靶向治疗肺曲霉病。
Ther Deliv. 2025 Feb;16(2):155-166. doi: 10.1080/20415990.2024.2441647. Epub 2024 Dec 23.

本文引用的文献

1
Cell viability and cytotoxicity assays: Biochemical elements and cellular compartments.细胞活力和细胞毒性测定：生化元素和细胞区室。
Cell Biochem Funct. 2024 Apr;42(3):e4007. doi: 10.1002/cbf.4007.
2
Antifungal Activity of Biosynthesized Silver Nanoparticles (AgNPs) against Causing Aspergillosis: Ultrastructure Study.生物合成银纳米颗粒（AgNPs）对引起曲霉病的真菌的抗真菌活性：超微结构研究
J Funct Biomater. 2022 Nov 15;13(4):242. doi: 10.3390/jfb13040242.
3
Development of Inhalable Nanostructured Lipid Carriers for Ciprofloxacin for Noncystic Fibrosis Bronchiectasis Treatment.
用于非囊性纤维化支气管扩张症治疗的环丙沙星吸入式纳米结构脂质载体的研制。
Int J Nanomedicine. 2021 Mar 25;16:2405-2417. doi: 10.2147/IJN.S286896. eCollection 2021.
4
Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal efficacy and lung retention.雾化表面活性杂化伏立康唑纳米粒用于肺部曲霉菌病显示出网格蛋白介导的细胞摄取、增强的抗真菌功效和肺部滞留。
J Nanobiotechnology. 2021 Jan 11;19(1):19. doi: 10.1186/s12951-020-00731-1.
5
A Critical Review on Emerging Trends in Dry Powder Inhaler Formulation for the Treatment of Pulmonary Aspergillosis.治疗肺曲霉病的干粉吸入剂配方新趋势的批判性综述
Pharmaceutics. 2020 Nov 28;12(12):1161. doi: 10.3390/pharmaceutics12121161.
6
Pulmonary delivery of liposomal dry powder inhaler formulation for effective treatment of idiopathic pulmonary fibrosis.用于有效治疗特发性肺纤维化的脂质体干粉吸入剂配方的肺部给药
Asian J Pharm Sci. 2018 Jan;13(1):91-100. doi: 10.1016/j.ajps.2017.08.005. Epub 2017 Aug 18.
7
Evaluation of co-delivery of colistin and ciprofloxacin in liposomes using an in vitro human lung epithelial cell model.采用体外人肺上皮细胞模型评价多黏菌素和环丙沙星脂质体共递送
Int J Pharm. 2019 Oct 5;569:118616. doi: 10.1016/j.ijpharm.2019.118616. Epub 2019 Aug 12.
8
Invasive Aspergillosis in solid-organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.实体器官移植受者侵袭性曲霉菌病：美国移植感染病学会实践社区指南。
Clin Transplant. 2019 Sep;33(9):e13544. doi: 10.1111/ctr.13544. Epub 2019 Apr 23.
9
Influence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale.粒径和形状对其边缘和壁附着的影响：对纳米到微米尺度药物输送载体设计的影响。
Nanoscale. 2018 Aug 16;10(32):15350-15364. doi: 10.1039/c8nr04042g.
10
A Review on Influence of Spray Drying Process Parameters on the Production of Medicinal Plant Powders.喷雾干燥工艺参数对药用植物粉末生产影响的综述
Curr Drug Discov Technol. 2019;16(4):340-354. doi: 10.2174/1570163815666180801152918.