Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospitals, Nordre Fasanvej 57, 2000, Frederiksberg, Denmark.
Section of Social Medicine, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, K 1014, København, Denmark.
Eur J Epidemiol. 2024 Aug;39(8):893-904. doi: 10.1007/s10654-024-01140-6. Epub 2024 Jul 27.
This study examines the hypotheses that the traits of higher IQ, longer education and taller height are associated with lower risk of death as compared to traits of low IQ, short education, and short height in men with schizophrenia compared to men without schizophrenia. In total, 937,919 men born 1939-59 and 1983-1997 with information from conscription were followed for incident schizophrenia in Danish registries. Higher levels of cognitive ability, longer education, and taller height were associated with fewer cases of schizophrenia. In a sub-sample of 652,368 men with information on body mass index, underweight was associated with more and overweight and obesity were associated with fewer cases of schizophrenia compared with normal weight. Higher cognitive ability, longer education, and taller height were associated with fewer deaths from both natural and unnatural causes in both men with and without schizophrenia. Underweight was associated with more deaths from natural and unnatural causes, whereas overweight and obesity were associated with more deaths from natural causes and fewer deaths from unnatural causes in both groups of men. Due to interaction, tall height and long educational duration were associated with fewer deaths from natural causes, and obesity was associated with fewer deaths from unnatural causes among men with schizophrenia compared to men without. In conclusion, traits in young adulthood are associated with higher mortality in men with and without schizophrenia, but traits of long educational duration and obesity seem to be especially important for lower mortality in men with schizophrenia.
与低智商、受教育程度低和身材矮小的特质相比，精神分裂症男性与非精神分裂症男性相比，较高的智商、较长的受教育程度和较高的身高与较低的死亡风险相关。共有 937,919 名 1939 年至 1959 年和 1983 年至 1997 年出生的男性在丹麦登记处接受了入伍信息，以记录精神分裂症的发病情况。较高的认知能力水平、较长的受教育程度和较高的身高与较少的精神分裂症病例相关。在有体重指数信息的 652,368 名男性亚样本中，与正常体重相比，体重过轻与更多的精神分裂症病例相关，而超重和肥胖与较少的精神分裂症病例相关。较高的认知能力、较长的受教育程度和较高的身高与精神分裂症和非精神分裂症男性的自然和非自然原因导致的死亡都较少相关。体重过轻与自然和非自然原因导致的死亡较多相关，而超重和肥胖与自然原因导致的死亡较多和非自然原因导致的死亡较少相关。由于存在交互作用，高身高和长教育年限与精神分裂症男性的自然原因导致的死亡减少有关，而肥胖与精神分裂症男性的非自然原因导致的死亡减少有关。总之，成年早期的特征与精神分裂症和非精神分裂症男性的死亡率较高有关，但较长的教育年限和肥胖的特征似乎对精神分裂症男性的死亡率降低尤为重要。
