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Successful clinical transplantation of hearts donated after circulatory death using direct procurement followed by hypothermic oxygenated perfusion: A report of the first 3 cases.

作者信息

Brouckaert Janne, Vandendriessche Katrien, Degezelle Karlien, Van de Voorde Kristof, De Burghgraeve Francis, Desmet Lars, Vlasselaers Dirk, Ingels Catherine, Dauwe Dieter, De Troy Erwin, Ceulemans Laurens J, Van Raemdonck Dirk, Monbaliu Diethard, Meyns Bart, Van den Eynde Raf, Rex Steffen, Van Cleemput Johan, Rega Filip

机构信息

Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.

Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.

出版信息

J Heart Lung Transplant. 2024 Nov;43(11):1907-1910. doi: 10.1016/j.healun.2024.07.018. Epub 2024 Jul 26.

DOI:10.1016/j.healun.2024.07.018
PMID:39069162
Abstract
摘要

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1
Successful clinical transplantation of hearts donated after circulatory death using direct procurement followed by hypothermic oxygenated perfusion: A report of the first 3 cases.采用直接获取后进行低温氧合灌注的方法对循环死亡后捐赠的心脏进行成功的临床移植：首例3例报告。
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Ex-situ oxygenated hypothermic machine perfusion in donation after circulatory death heart transplantation following either direct procurement or in-situ normothermic regional perfusion.在直接获取或原位常温区域灌注后，采用体外充氧低温机器灌注进行捐赠后循环死亡心脏移植。
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Hypothermic, oxygenated perfusion (HOPE) provides cardioprotection via succinate oxidation prior to normothermic perfusion in a rat model of donation after circulatory death (DCD).低温氧合灌注（HOPE）通过在捐赠后循环死亡（DCD）大鼠模型中进行常温灌注之前的琥珀酸氧化提供心脏保护。
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Transplantation of Hearts Donated after Circulatory Death.循环性死亡后捐献心脏的移植
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引用本文的文献

1
Cardioplegic Machine Perfusion of Hearts Donated after Circulatory Death.心脏死亡后捐献心脏的心脏停搏液机器灌注
J Cardiovasc Transl Res. 2025 Sep 8. doi: 10.1007/s12265-025-10694-z.
2
Preserving the future of heart transplantation.维护心脏移植的未来。
Nat Rev Cardiol. 2025 Jun;22(6):391-392. doi: 10.1038/s41569-025-01146-x.
3
Brief hypothermic oxygenated perfusion provides cardioprotection in a pig model of donation after circulatory death.短暂低温氧合灌注可为循环性死亡后供体猪模型提供心脏保护。
Eur J Cardiothorac Surg. 2025 Mar 4;67(3). doi: 10.1093/ejcts/ezaf061.
4
Heart Transplantation and Donation After Circulatory Death in Children. A Review of the Technological, Logistical and Ethical Framework.儿童心脏移植与循环性死亡后的器官捐献。技术、后勤及伦理框架综述。
Transpl Int. 2025 Feb 14;38:13801. doi: 10.3389/ti.2025.13801. eCollection 2025.
5
Clinical Outcomes of Machine Perfusion and Temperature Control Systems in Heart Transplantation: Where We Stand.心脏移植中机器灌注和温度控制系统的临床结果：我们的现状
J Clin Med. 2025 Feb 11;14(4):1152. doi: 10.3390/jcm14041152.
6
The Rapidly Evolving Landscape of DCD Heart Transplantation.脑死亡后心脏移植的快速演变格局
Curr Cardiol Rep. 2024 Dec;26(12):1499-1507. doi: 10.1007/s11886-024-02148-w. Epub 2024 Oct 9.