Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, Mississippi 39762, United States.
J Equine Vet Sci. 2024 Oct;141:105151. doi: 10.1016/j.jevs.2024.105151. Epub 2024 Jul 26.
Insulin dysregulation (ID), core to equine metabolic syndrome, may present without obesity. Testing for ID risk is commonly based on breed and obese phenotype but might be valuable for non-obese stock-type horses. This study aimed to determine the prevalence of ID in non-obese stock-type horses and evaluate if morphometric neck measurements (MNM) correlate with ID. Sixty-two, non-obese (BCS 5, range 2.5-6/9) stock-type horses were assessed for MNM: neck circumference at 25%, 50% (NC50), and 75% (NC75) length, and crest height. An oral sugar test (OST; 0.15 mL/kg BW corn syrup) was performed with blood taken pre- and 60 min post-OST for insulin (PREI, POSTI) and glucose (PREG, POSTG). Insulin dysregulation was defined as insulin concentration > 45 µIU/mL POSTI. Three of 62 horses were ID (4.8%; 95% CI 1.0%-13.5%). Horses with ID had greater PREG (121.0 ± 7.56 vs. 105.3 ± 1.72 mg/dL; LS means ± SEM; P = 0.04) and PREI (15.7 ± 2.63 vs. 10.5 ± 0.59 µIU/mL; P = 0.05) than normal responders. Mares had greater PREI than geldings (11.7 ± 0.76 vs. 9.4 ± 0.89 µIU/mL; P = 0.04). Stepwise regression indicated a weak relationship with crest height and POSTG (y = 51.27 + (0.88 x NC50); R = 0.09; P = 0.02). Post-glucose correlated with NC50 (r = 0.30; P = 0.04) and NC75 (r = 0.29; P = 0.03). This study showed 4.8% of non-obese horses had ID, warranting testing irrespective of phenotype, but only a weak association between MNM and POSTG was found.
胰岛素功能紊乱（ID）是马代谢综合征的核心，可能在不肥胖的情况下出现。ID 风险检测通常基于品种和肥胖表型，但对于非肥胖的种马型马可能具有价值。本研究旨在确定非肥胖种马型马 ID 的患病率，并评估形态颈部测量（MNM）是否与 ID 相关。对 62 匹非肥胖（BCS 5，范围 2.5-6/9）种马型马进行 MNM 评估：颈围在 25%（NC50）、50%（NC50）和 75%（NC75）长度处，以及嵴高度。进行口服糖耐量试验（OST；0.15 mL/kg BW 玉米糖浆），在 OST 前和 60 分钟后采血，用于检测胰岛素（PREI、POSTI）和血糖（PREG、POSTG）。将胰岛素浓度>45 µIU/mL POSTI 定义为 ID。62 匹马中有 3 匹（4.8%；95%CI 1.0%-13.5%）为 ID。ID 马的 PREG（121.0 ± 7.56 与 105.3 ± 1.72 mg/dL；LS 均值 ± SEM；P = 0.04）和 PREI（15.7 ± 2.63 与 10.5 ± 0.59 µIU/mL；P = 0.05）均高于正常反应者。母马的 PREI 高于公马（11.7 ± 0.76 与 9.4 ± 0.89 µIU/mL；P = 0.04）。逐步回归表明与嵴高度和 POSTG 呈弱相关（y = 51.27 +（0.88 x NC50）；R = 0.09；P = 0.02）。POSTG 与 NC50（r = 0.30；P = 0.04）和 NC75（r = 0.29；P = 0.03）相关。本研究表明，4.8%的非肥胖马存在 ID，无论表型如何，都需要进行检测，但仅发现 MNM 与 POSTG 之间存在微弱关联。
