Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United States.
Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, United States; Nebraska Redox Biology Center, Lincoln, NE, United States; Fred & Pamela Buffett Cancer Center, Omaha, NE, United States.
Adv Cancer Res. 2024;162:75-97. doi: 10.1016/bs.acr.2024.05.001. Epub 2024 May 22.
Our understanding of the roles that mitochondria play in cellular physiology has evolved drastically-from a mere cellular energy supplier to a crucial regulator of metabolic and signaling processes, particularly in the context of development and progression of human diseases such as cancers. The present review examines the role of OMA1, a conserved, redox-sensitive metallopeptidase in cancer biology. OMA1's involvement in mitochondrial quality control, redox activity, and stress responses underscores its potential as a novel target in cancer diagnosis and treatment. However, our incomplete understanding of OMA1's regulation and structural detail presents ongoing challenges to target OMA1 for therapeutic purposes. Further exploration of OMA1 holds promise in uncovering novel insights into cancer mechanisms and therapeutic strategies. In this chapter, we briefly summarize our current knowledge about OMA1, its redox-regulation, and emerging role in certain cancers.
我们对线粒体在细胞生理学中所扮演角色的理解已经发生了巨大的变化——从仅仅是细胞的能量供应者，到代谢和信号过程的关键调节者，尤其是在癌症等人类疾病的发展和进展方面。本综述探讨了 OMA1 在癌症生物学中的作用，OMA1 是一种保守的、氧化还原敏感的金属肽酶。OMA1 在线粒体质量控制、氧化还原活性和应激反应中的作用突出了其作为癌症诊断和治疗新靶点的潜力。然而，我们对 OMA1 调节和结构细节的理解不完整，这对以 OMA1 为靶点进行治疗提出了持续的挑战。进一步探索 OMA1 有望揭示癌症机制和治疗策略的新见解。在这一章中，我们简要总结了我们目前对 OMA1 的了解，包括其氧化还原调节以及在某些癌症中的新兴作用。
