Smets Anne M, Sofia Carmelo, Bruno Costanza, Ključevšek Damjana, Lobo Maria Luisa, Napolitano Marcello, Ozcan H Nursun, Stafrace Samuel, Petit Philippe, Müller Lil-Sofie Ording
Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Department of Biomedical Sciences and Morphologic and Functional Imaging, University of Messina, Messina, Italy.
Pediatr Radiol. 2025 Apr;55(4):660-673. doi: 10.1007/s00247-024-05992-8. Epub 2024 Jul 29.
Precocious puberty in girls is defined by the appearance of secondary sex characteristics before the age of 8 years. Precocious puberty is either peripheral or central. In most cases, the cause of central precocious puberty is unknown. Rapidly progressive forms of central precocious puberty may benefit from puberty suppression to prevent compromised final height and psychosocial problems related to the physical changes. Idiopathic central precocious puberty in girls can be a challenging diagnosis. Clinical examination, evaluation of growth charts, bone age, and hormonal tests are part of the workup. The role of pelvic ultrasound to evaluate pubertal features of the internal genitalia in this context is controversial. In this paper, we have reviewed the literature to find the scientific bases for several proposed ultrasound parameters and cutoff values for the determination of onset of puberty in girls with suspected central precocious puberty. There are no reliable cutoffs for the measurements of uterus and ovaries for the diagnosis of central precocious puberty and there is overlap in the appearance of the organs in both prepubertal and pubertal girls. The interpretation of the findings on pelvic ultrasound must be done with caution and always in close communication with the referring clinicians.
女孩性早熟的定义是在8岁之前出现第二性征。性早熟分为外周性和中枢性。在大多数情况下,中枢性性早熟的病因不明。中枢性性早熟的快速进展型可能受益于性发育抑制,以防止最终身高受损以及与身体变化相关的心理社会问题。女孩特发性中枢性性早熟可能是一个具有挑战性的诊断。临床检查、生长图表评估、骨龄和激素检测是检查的一部分。在这种情况下,盆腔超声评估内生殖器青春期特征的作用存在争议。在本文中,我们回顾了文献,以寻找一些提议的超声参数和临界值的科学依据,这些参数和临界值用于确定疑似中枢性性早熟女孩的青春期开始时间。对于中枢性性早熟的诊断,子宫和卵巢测量没有可靠的临界值,青春期前和青春期女孩的器官外观存在重叠。盆腔超声检查结果的解释必须谨慎进行,并且始终与转诊的临床医生密切沟通。