State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, People's Republic of China.
Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, People's Republic of China.
Biomed Mater. 2024 Jul 29;19(5). doi: 10.1088/1748-605X/ad6548.
Skin aging, characterized by reduced regeneration, chronic inflammation, and heightened skin cancer risk, poses a significant challenge. Collagen fillers have emerged as a potential solution for skin rejuvenation by stimulating collagen regeneration. However, their clinical efficacy is limited by inherent instability and vulnerability todegradation by collagenase. Chemical cross-linking presents a promising approach to enhance stability, but it carries risks such as cytotoxicity, calcification, and discoloration. Here, we introduce a highly durable 1,4-butanediol diglycidyl ether (BDDE) cross-linked collagen filler for skin rejuvenation. BDDE effectively cross-links collagen, resulting in fillers with exceptional mechanical strength and injectability. These fillers demonstrate favorable stability and durability, promoting proliferation, adhesion, and spreading of human foreskin fibroblast-1 cellsstudies confirm enhanced collagen regeneration without inducing calcification. BDDE cross-linked collagen fillers offer promising prospects for medical cosmetology and tissue regeneration.
皮肤老化的特征是再生能力降低、慢性炎症和皮肤癌风险增加，这是一个重大挑战。胶原蛋白填充剂通过刺激胶原蛋白再生，成为皮肤年轻化的一种潜在解决方案。然而，其临床疗效受到固有不稳定性和易被胶原酶降解的限制。化学交联提供了一种增强稳定性的有前途的方法，但它存在细胞毒性、钙化和变色等风险。在这里，我们介绍了一种用于皮肤年轻化的高度耐用的 1,4-丁二醇二缩水甘油醚 (BDDE) 交联胶原蛋白填充剂。BDDE 有效地交联胶原蛋白，使填充剂具有出色的机械强度和可注射性。这些填充剂表现出良好的稳定性和耐久性，促进了人包皮成纤维细胞-1 细胞的增殖、粘附和扩展研究证实，在不引起钙化的情况下，促进了胶原蛋白的再生。BDDE 交联胶原蛋白填充剂为医学美容和组织再生提供了有前途的前景。
