Department of Orthopaedic Surgery, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
The Fourth Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330100, China.
Biomark Med. 2024;18(13-14):639-647. doi: 10.1080/17520363.2024.2366160. Epub 2024 Jul 29.
Osteosarcoma (OS), a primary human malignant tumor that affects the bones, mostly arises in children and adolescents. Even though surgical resection followed by radiotherapy and chemotherapy has improved the survival rate up to 60%, the long-term positive effect for most patients with OS is not satisfactory. Hence, elucidating the specific mechanisms involved in the pathogenesis of OS is particularly important. Aurora-B, a serine/threonine kinase, plays a crucial role in centrosome regulation, spindle formation and chromosomal separation during mitosis. It has been found that Aurora-B overexpression is related to the occurrence and development of several malignant tumors, including OS. This article summarizes the role of Aurora-B in the invasion and metastasis of OS.
骨肉瘤（OS）是一种主要发生在骨骼的人类原发性恶性肿瘤，多发生于儿童和青少年。尽管手术切除后辅以放疗和化疗，患者的生存率提高到了 60%，但对于大多数 OS 患者来说，长期的积极效果并不令人满意。因此，阐明 OS 发病机制中涉及的具体机制尤为重要。Aurora-B 是一种丝氨酸/苏氨酸激酶，在有丝分裂过程中对中心体调节、纺锤体形成和染色体分离起着关键作用。已经发现 Aurora-B 的过度表达与几种恶性肿瘤的发生和发展有关，包括骨肉瘤。本文总结了 Aurora-B 在骨肉瘤侵袭和转移中的作用。
