Maini Deepinder Kaur, Dixit Anubhuti, Sharma Bipan, Nanda Satyan, Rehani Varun, Anand Rajiv
Amity Institute of Neuropsychology and Neurosciences, Amity University, Noida, India.
Department of Neurology, BLK Max Super Speciality Hospital, Delhi, India.
J Family Med Prim Care. 2024 Jul;13(7):2623-2627. doi: 10.4103/jfmpc.jfmpc_1558_23. Epub 2024 Jun 28.
To study demographic and clinical profiles of Guillain Barre syndrome (GBS) in the pre-pandemic and coronavirus disease 2019 (COVID-19) pandemic era and to compare the GBS incidence, severity, and its outcome in the pre-pandemic and pandemic eras.
This is a 4-year retrospective study done in a tertiary care hospital in Delhi, India, between March 2018 and March 2022. Patients were divided into the pre-pandemic era and pandemic era (2 years before and 2 years after March 2020).
The number of patients (N) was 25 in the pandemic/vaccine era, while N = 49 in the pre-pandemic era. The mean duration of hospitalization was significantly higher ( = 0.03) during the pandemic era (10.68 ± 6.67 days) compared to the pre-pandemic era (7.59 ± 3.55 days). There was no statistical difference in age ( = 0.56), gender ( = 0.70), GBS variants ( = 0.40), clinical spectrum, antecedent infection ( = 0.91), Hughes Disability Score on admission and discharge ( = 0.93 and = 0.52, respectively), respiratory involvement requiring a ventilator ( = 0.19), and mortality ( = 0.26) in both the eras.
Our study showed no association of the incidence of GBS with the ongoing COVID-19 pandemic. The mean hospitalization days were significantly increased during COVID-19 in view of associated respiratory involvement. The commonly held hypothesis of the increase in GBS cases during the pandemic/vaccine era has not been observed in our study.
研究大流行前和2019年冠状病毒病（COVID-19）大流行时代吉兰-巴雷综合征（GBS）的人口统计学和临床特征，并比较大流行前和大流行时代GBS的发病率、严重程度及其结局。
这是一项在印度德里一家三级护理医院进行的为期4年的回顾性研究，时间跨度为2018年3月至2022年3月。患者被分为大流行前时代和大流行时代（2020年3月前2年和后2年）。
大流行/疫苗时代的患者数量（N）为25例，而大流行前时代N = 49例。与大流行前时代（7.59 ± 3.55天）相比，大流行时代的平均住院时间显著更长（P = 0.03）（10.68 ± 6.67天）。两个时代在年龄（P = 0.56）、性别（P = 0.70）、GBS亚型（P = 0.40）、临床谱、前驱感染（P = 0.91）、入院和出院时的休斯残疾评分（分别为P = 0.93和P = 0.52）、需要呼吸机的呼吸受累情况（P = 0.19）以及死亡率（P = 0.26）方面均无统计学差异。
我们的研究表明GBS的发病率与正在进行的COVID-19大流行没有关联。鉴于相关的呼吸受累情况，COVID-19期间平均住院天数显著增加。我们的研究未观察到普遍认为的大流行/疫苗时代GBS病例增加的假设。
