Sekiguchi Kazumasa, Matsuzono Kosuke, Mashiko Takafumi, Koide Reiji, Fujimoto Shigeru
Division of Neurology, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
SAGE Open Med Case Rep. 2024 Jul 26;12:2050313X241267082. doi: 10.1177/2050313X241267082. eCollection 2024.
Some neurological complications are associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A 74-year-old man was diagnosed with infection by SARS-CoV-2. Eighteen days after SARS-CoV-2 infection, he developed disturbed consciousness and aseptic meningoencephalitis. An analysis of cerebrospinal flood revealed an elevated cell count (184/μL) and protein level (260 mg/dL). Cranial magnetic resonance imaging showed no abnormalities. By contrast, I-N-isopropyl-p-iodoamphetamine single-photon emission computed tomography showed a significant decrease in cerebral blood flow (CBF) in the left parietal and occipital lobes. He died suddenly 3 months after being transferred to a rehabilitation clinic without any clear cause of death. The SARS-CoV-2 infection can cause aseptic meningoencephalitis with a distinctive decrease in CBF pattern without magnetic resonance image abnormality or intracranial artery stenosis.
一些神经系统并发症与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）有关。一名74岁男性被诊断感染SARS-CoV-2。在感染SARS-CoV-2 18天后，他出现意识障碍和无菌性脑膜脑炎。脑脊液分析显示细胞计数（184/μL）和蛋白质水平（260 mg/dL）升高。头颅磁共振成像未显示异常。相比之下，I-N-异丙基-p-碘安非他明单光子发射计算机断层扫描显示左顶叶和枕叶脑血流量（CBF）显著降低。在转至康复诊所3个月后，他突然死亡，死因不明。SARS-CoV-2感染可导致无菌性脑膜脑炎，伴有CBF模式明显降低，而无磁共振图像异常或颅内动脉狭窄。
