Alizadeh Madeline, Zisman Erin, Wong Uni
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
SAGE Open Med Case Rep. 2024 Jul 26;12:2050313X241254732. doi: 10.1177/2050313X241254732. eCollection 2024.
Hidradenocarcinoma is a locally aggressive malignancy of the sweat glands, most commonly found on the head, neck, and upper body. Although rare, it has been seen in patients with hidradenitis supparativa, who have an increased risk of non-melanoma skin cancers. Ustekinumab, a biologic agent used to treat inflammatory bowel disease, has been associated with development of cancer in some patients. We present a case of a 36-year-old female with hidradenitis supparativa and Crohn's disease who developed hidradenocarcinoma in setting of ustekinumab use, demonstrating the need for further study of the relationship between biologic therapy and malignancy.
汗腺癌是一种局部侵袭性的汗腺恶性肿瘤，最常见于头部、颈部和上半身。虽然罕见，但在化脓性汗腺炎患者中也有发现，这些患者患非黑素瘤皮肤癌的风险增加。乌司奴单抗是一种用于治疗炎症性肠病的生物制剂，在一些患者中与癌症的发生有关。我们报告一例36岁女性患者，患有化脓性汗腺炎和克罗恩病，在使用乌司奴单抗的情况下发生了汗腺癌，这表明需要进一步研究生物治疗与恶性肿瘤之间的关系。
