AMPKα亚基在阿尔茨海默病中的作用：深入分析与未来展望。
The role of AMPKα subunit in Alzheimer's disease: In-depth analysis and future prospects.
作者信息
Xia Lingqiong, Chen Jianhua, Huang Juan, Lin Xianmei, Jiang Jingyu, Liu Tingting, Huang Nanqu, Luo Yong
机构信息
Department of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.
Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Guizhou, China.
出版信息
Heliyon. 2024 Jul 6;10(13):e34254. doi: 10.1016/j.heliyon.2024.e34254. eCollection 2024 Jul 15.
The AMP-activated protein kinase α (AMPKα) subunit is the catalytic subunit in the AMPK complex, playing a crucial role in AMPK activation. It has two isoforms: AMPKα1 and AMPKα2. Emerging evidence suggests that the AMPKα subunit exhibits subtype-specific effects in Alzheimer's disease (AD). This review discusses the role of the AMPKα subunit in the pathogenesis of AD, including its impact on β-amyloid (Aβ) pathology, Tau pathology, metabolic disorders, inflammation, mitochondrial dysfunction, inflammasome and pyroptosis. Additionally, it reviews the distinct roles of its isoforms, AMPKα1 and AMPKα2, in AD, which may provide more precise targets for future drug development in AD.
AMP激活的蛋白激酶α（AMPKα）亚基是AMPK复合物中的催化亚基，在AMPK激活中起关键作用。它有两种亚型：AMPKα1和AMPKα2。越来越多的证据表明，AMPKα亚基在阿尔茨海默病（AD）中表现出亚型特异性作用。本文综述了AMPKα亚基在AD发病机制中的作用，包括其对β-淀粉样蛋白（Aβ）病理、Tau病理、代谢紊乱、炎症、线粒体功能障碍、炎性小体和细胞焦亡的影响。此外，还综述了其亚型AMPKα1和AMPKα2在AD中的不同作用，这可能为未来AD药物开发提供更精确的靶点。
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