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低前列腺特异性抗原水平下尿道前列腺癌复发

Prostate cancer recurrence in the urethra with low PSA.

作者信息

Ananthapadmanabhan Shravankrishna, Williams Zoe, Wang Henry, Combes Alexander, Wong Veronica, Thangasamy Isaac

机构信息

Nepean Urology Research Group, Nepean Hospital, Kingswood, New South Wales, 2747, Australia.

Department of Nuclear Medicine and PET, Nepean Hospital, Kingswood, New South Wales, 2747, Australia.

出版信息

Urol Case Rep. 2024 Jul 3;55:102787. doi: 10.1016/j.eucr.2024.102787. eCollection 2024 Jul.

DOI:10.1016/j.eucr.2024.102787
PMID:39071853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11279688/
Abstract

When localised prostate cancer recurs after treatment, it occurs predictably in sites such as the prostatic bed, pelvic lymph nodes, spine, lung, and liver. Urethral metastasis of prostate cancer is exceedingly rare. We report a case of urethral recurrence of prostate cancer presenting as new lower urinary tract symptoms in an 82-year-old male 10 years after robotic radical prostatectomy with a very low PSA level of 0.05μg/L. This rare case highlights the need to maintain a degree of suspicion for prostate cancer recurrence in patients with a late onset of or changing lower urinary tract symptoms after radical prostatectomy.

摘要

当局限性前列腺癌治疗后复发时,其复发部位可预测,如前列腺床、盆腔淋巴结、脊柱、肺和肝脏。前列腺癌尿道转移极为罕见。我们报告一例前列腺癌尿道复发病例,该病例为一名82岁男性,在机器人辅助根治性前列腺切除术后10年出现新的下尿路症状,其前列腺特异性抗原(PSA)水平极低,仅为0.05μg/L。这一罕见病例凸显了对于根治性前列腺切除术后出现较晚或变化的下尿路症状的患者,需要对前列腺癌复发保持一定程度的怀疑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5352/11279688/35cf8ddb454c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5352/11279688/35cf8ddb454c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5352/11279688/35cf8ddb454c/gr1.jpg

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本文引用的文献

1
Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review.雄激素非依赖型前列腺癌在尿路中的多处转移:两例病例报告及文献复习。
BMC Med Genomics. 2022 May 21;15(1):118. doi: 10.1186/s12920-022-01267-z.
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EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.EAU-EANM-ESTRO-ESUR-SIOG 前列腺癌指南-2020 版更新。第 1 部分:筛查、诊断和以治愈为目的的局部治疗。
Eur Urol. 2021 Feb;79(2):243-262. doi: 10.1016/j.eururo.2020.09.042. Epub 2020 Nov 7.
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A case of urethral metastasis of castration-resistant prostate cancer successfully cured with CyberKnife radiosurgery.
1例去势抵抗性前列腺癌尿道转移经射波刀放射外科手术成功治愈
Urol Case Rep. 2020 Jul 13;33:101346. doi: 10.1016/j.eucr.2020.101346. eCollection 2020 Nov.
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Metastatic Prostate Cancer to the Urethra Masquerading as Urothelial Carcinoma.伪装成尿路上皮癌的转移性前列腺癌累及尿道
Urol Case Rep. 2016 May 6;7:33-6. doi: 10.1016/j.eucr.2016.03.007. eCollection 2016 Jul.
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Anatomical Patterns of Recurrence Following Biochemical Relapse in the Dose Escalation Era of External Beam Radiotherapy for Prostate Cancer.前列腺癌外照射放疗剂量递增时代生化复发后的复发解剖学模式
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Zhonghua Nan Ke Xue. 2013 Dec;19(12):1107-10.
7
Isolated recurrence of ductal prostate cancer to anterior urethra.导管前列腺癌孤立性复发至前尿道。
Urology. 2006 Aug;68(2):428.e13-5. doi: 10.1016/j.urology.2006.03.024.
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Intraductal carcinoma of the prostate metastatic to the penile urethra: a rare demonstration of two morphologic patterns of tumor growth.
Pathology. 1998 May;30(2):218-21. doi: 10.1080/00313029800169306.
9
Carcinoma of the prostate with urethral metastases.伴有尿道转移的前列腺癌。
J Urol. 1972 Dec;108(6):901-4. doi: 10.1016/s0022-5347(17)60902-9.