Gorbachevskii A V, Kicherova O A, Reikhert L I
Tyumen State Medical University, Tyumen, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(6):20-25. doi: 10.17116/jnevro202412406120.
Currently, more and more importance is being attached to the interaction of brain neurons with astrocytes in order to study the pathogenesis, and in the future, to develop methods for the prevention, early diagnosis and treatment of neurodegenerative diseases of the brain. In this review article, the authors attempt to demonstrate the role of astrocytes, disturbances in circadian rhythms, sleep-wake patterns, and light pollution in the development of Alzheimer's disease. Based on the analysis of literature data, possible mechanisms of synchronization and desynchronization of these processes are presented.
目前，为了研究发病机制，并在未来开发预防、早期诊断和治疗脑退行性疾病的方法，脑神经元与星形胶质细胞的相互作用正受到越来越多的重视。在这篇综述文章中，作者试图阐明星形胶质细胞、昼夜节律紊乱、睡眠-觉醒模式和光污染在阿尔茨海默病发展中的作用。基于文献数据的分析，提出了这些过程同步和不同步的可能机制。
