Zaharova V V, Ruina E A, Antipenko E A
Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(6):139-144. doi: 10.17116/jnevro2024124061139.
Stiff-person syndrome is a rare autoimmune disorder manifested by stiffness in the trunk and proximal limb muscles and painful muscle spasms in them. The disease is associated with the production of glutamate decarboxylase autoantibodies, an enzyme converting glutamate into gamma-aminobutyric acid. An increase of anti-GAD antibody serum levels above 10.000 IU/mL is specific for stiff-person syndrome. Our own clinical observation of a patient diagnosed with stiff-person syndrome is presented.
僵人综合征是一种罕见的自身免疫性疾病，表现为躯干和近端肢体肌肉僵硬以及肌肉疼痛性痉挛。该疾病与谷氨酸脱羧酶自身抗体的产生有关，谷氨酸脱羧酶是一种将谷氨酸转化为γ-氨基丁酸的酶。抗谷氨酸脱羧酶抗体血清水平高于10000 IU/mL对僵人综合征具有特异性。本文介绍了我们对一名诊断为僵人综合征患者的临床观察。
