Support Unit for Animal Resources Development, Research Resources Division, RIKEN Center for Brain Science.
Support Unit for Animal Resources Development, Research Resources Division, RIKEN Center for Brain Science;
J Vis Exp. 2024 Jul 12(209). doi: 10.3791/66768.
Wasting marmoset syndrome (WMS), a serious disease in captive common marmoset (Callithrix jacchus) colonies, is associated with a high mortality rate. The specific cause of WMS is still unclear and there are few effective treatments. Previously, we had reported a tranexamic acid therapy with supportive measures as a useful treatment for WMS. In the present study, we describe the modified method: a combination of 0.1 mL of 5% tranexamic acid subcutaneously five times per week, 2.0 mL of amino acid formulation intravenously three times per week, 5.0 mL of Ringer's lactate with 0.1 mL of a vitamin formulation subcutaneously three times per week, and oral administration of 0.1 mL of an iron formulation five times per week. We also describe how to administer the solution intravenously via the saphenous vein with a tip of restraining the animal, as well as the detailed methods for oral and subcutaneous administration. The modified methods have comparable efficiency to the original WMS treatment method.
废用综合征（Wasting marmoset syndrome，WMS）是圈养绒猴（Callithrix jacchus）种群中一种严重的疾病，具有较高的死亡率。WMS 的具体病因尚不清楚，且治疗方法有限。先前，我们曾报道过氨甲环酸联合支持治疗对 WMS 具有一定疗效。在本研究中，我们描述了改良的治疗方法：每周皮下注射 5%氨甲环酸 0.1 mL 五次、每周静脉注射氨基酸制剂 2.0 mL 三次、每周皮下注射 5.0 mL 林格氏乳酸盐和 0.1 mL 维生素制剂三次，以及每周口服 0.1 mL 铁制剂五次。我们还描述了如何通过动物腿部的束缚尖端，经隐静脉进行静脉内给药，以及口服和皮下给药的详细方法。改良方法与原始 WMS 治疗方法具有相似的疗效。
