State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi, China.
Jiangxi Provincial Selenium-rich Product Quality Supervision and Inspection Centre/Ganzhou Comprehensive Inspection and Testing Institute, Ganzhou, Jiangxi, China.
J Food Sci. 2024 Sep;89(9):5870-5883. doi: 10.1111/1750-3841.17174. Epub 2024 Jul 29.
Hyperlipidemia has been suggested to be associated with dysregulation of lipid metabolism and gut microbiota. The present study prepared microencapsulated rice bran (MRB) with high stability based on in situ rice bran oil embedding and investigated the effects of MRB on lipid metabolism and gut microbiota in hyperlipidemic mice induced by high-fat diet (HFD). Results showed that compared to HFD fed mice, lipid levels in serum and hepatic lipid accumulation were reduced in mice fed with MRB, which was potentially associated with the fact that MRB decreased the expression of genes related to lipogenesis (Srebp1c, Acc, Hmgcr, and Fas) and increased the expression of genes related to lipid catabolism (Hsl, Atgl) and oxidation (Acox, Cpt1, Ucp1) (p < 0.05). In gut, MRB supplementation significantly elevated the abundance of beneficial bacteria, such as Dubosiella and Faecalibaculum. In addition, significant increase in short-chain fatty acid was observed in mice from MRB groups when compared to HFD groups (p < 0.05). Overall, this study suggested that MRB could alleviate the hyperlipidemia induced by HFD, which was related to the alteration of lipid metabolism and gut microbiota.
高脂血症与脂质代谢和肠道微生物群的失调有关。本研究基于原位米糠油包埋法制备了高稳定性的微囊化米糠（MRB），并研究了 MRB 对高脂肪饮食（HFD）诱导的高脂血症小鼠脂质代谢和肠道微生物群的影响。结果表明，与 HFD 喂养的小鼠相比，MRB 喂养的小鼠血清和肝脂质蓄积中的脂质水平降低，这可能与 MRB 降低与脂肪生成相关的基因（Srebp1c、Acc、Hmgcr 和 Fas）的表达，增加与脂质分解代谢（Hsl、Atgl）和氧化（Acox、Cpt1、Ucp1）相关的基因的表达有关（p<0.05）。在肠道中，MRB 补充剂显著增加了有益细菌的丰度，如 Dubosiella 和 Faecalibaculum。此外，与 HFD 组相比，MRB 组小鼠的短链脂肪酸含量显著增加（p<0.05）。总的来说，本研究表明，MRB 可以缓解 HFD 引起的高脂血症，这与脂质代谢和肠道微生物群的改变有关。
