Department of Organ and Tissue donation and Transplantation, Pathology, NHS Blood and Transplant, Bristol, UK.
Department of Pathology, NHS Blood and Transplant, Bristol, UK.
Transpl Infect Dis. 2024 Nov;26 Suppl 1:e14351. doi: 10.1111/tid.14351. Epub 2024 Jul 27.
A biovigilance program that has oversight of the entire organ and tissue donation and transplantation pathways underpins the quality and safety system in the United Kingdom.
A synopsis of the microbiological characterization of potential deceased organ donors and the processes for notification and investigation of possible donor-derived infections are described. A summary of the outcome of investigations performed over a 10-year period and a subset data frame of 5 years showing the proportion of infection incidents in relation to other incident types are also presented.
A single, centralized system overseeing the entire donation and transplantation pathway has become an essential part of transplantation practice across the United Kingdom. Revision of processes and management options, awareness of clinical conditions, and review of guidance are some examples of benefits gained over time. Transmission figures provided reflect the UK setting; these should be interpreted in context, as donor and recipient epidemiology differs across regions and nations. Despite a well-established system in place, under reporting of cases continues to occur, with ongoing efforts to reassure professionals and patients of the true benefits of biovigilance in driving improvements in practice and patient outcomes.
英国建立了一个涵盖整个器官和组织捐献与移植流程的生物警戒项目，为质量和安全体系提供支撑。
本文概述了潜在器官捐献者的微生物特征，以及针对可能的供者源性感染进行通报和调查的流程。文中还总结了 10 年来开展调查的结果，并提供了一个 5 年的子数据集，展示了与其他类型事件相比感染事件的比例。
在英国，一个覆盖整个捐献和移植流程的单一集中式系统已成为移植实践不可或缺的一部分。随着时间的推移，不断对流程和管理选项进行修订，提高对临床情况的认识，并对指南进行审查，从中获得了诸多益处。提供的传播数据反映了英国的情况；这些数据应在上下文中进行解释，因为供者和受者的流行病学在不同地区和国家存在差异。尽管已经建立了完善的系统，但仍存在漏报病例的情况，我们正在不断努力，让专业人员和患者相信，通过生物警戒来推动实践和患者结局的改善，确实能带来真正的益处。
