Ylä-Herttuala S
Acta Med Scand Suppl. 1985;701:7-14. doi: 10.1111/j.0954-6820.1985.tb08885.x.
Atherosclerosis is a multifactorial disease. A unified model for the lesion development reveals many connections between the response-to-injury hypothesis and the lipid hypothesis. Various cellular uptake mechanisms for native and modified lipoproteins are discussed with respect to foam cell formation and lesion development. The role of arterial smooth muscle cells in atherogenesis is emphasized. Preliminary results of biochemical analyses from the coronary arteries of accidentally died Finnish children and adults reveal that the accumulation of plasma-derived cholesteryl esters in young children began early in childhood, long before the vessels became macroscopically affected and changes in arterial glycosaminoglycans correlated significantly with the accumulation of cholesteryl esters.
动脉粥样硬化是一种多因素疾病。病变发展的统一模型揭示了损伤反应假说和脂质假说之间的许多联系。就泡沫细胞形成和病变发展而言，讨论了天然和修饰脂蛋白的各种细胞摄取机制。强调了动脉平滑肌细胞在动脉粥样硬化发生中的作用。对意外死亡的芬兰儿童和成人冠状动脉进行生化分析的初步结果表明，幼儿血浆源性胆固醇酯的积累在儿童早期就已开始，远在血管出现宏观病变之前，且动脉糖胺聚糖的变化与胆固醇酯的积累显著相关。
