Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province, China.
Institute of Stroke Research, Soochow University, Suzhou, Jiangsu Province, China.
Med Gas Res. 2024 Dec 1;14(4):186-191. doi: 10.4103/2045-9912.385939. Epub 2023 Sep 17.
Alzheimer's disease (AD), the most prevalent cause of dementia, is a progressive neurodegenerative condition that commences subtly and inexorably worsens over time. Despite considerable research, a specific drug that can fully cure or effectively halt the progression of AD remains elusive. Nitric oxide (NO), a crucial signaling molecule in the nervous system, is intimately associated with hallmark pathological changes in AD, such as amyloid-beta deposition and tau phosphorylation. Several therapeutic strategies for AD operate through the nitric oxide synthase/NO system. However, the potential neurotoxicity of NO introduces an element of controversy regarding its therapeutic utility in AD. This review focuses on research findings concerning NO's role in experimental AD and its underlying mechanisms. Furthermore, we have proposed directions for future research based on our current comprehension of this critical area.
阿尔茨海默病（AD）是最常见的痴呆症病因，是一种进行性神经退行性疾病，其症状起初微妙，而后逐渐加重且不可逆转。尽管进行了大量研究，但仍未发现能够完全治愈或有效阻止 AD 进展的特定药物。一氧化氮（NO）是神经系统中一种至关重要的信号分子，与 AD 的标志性病理变化密切相关，如β淀粉样蛋白沉积和tau 磷酸化。几种 AD 的治疗策略都通过一氧化氮合酶/NO 系统发挥作用。然而，NO 的潜在神经毒性使得其在 AD 中的治疗应用存在争议。本综述重点关注有关 NO 在实验性 AD 中的作用及其潜在机制的研究发现。此外，我们根据对这一关键领域的现有理解，提出了未来研究的方向。
