Brain and Nerve Research Laboratory, Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Med Gas Res. 2024 Sep 1;14(3):96-101. doi: 10.4103/2045-9912.385946. Epub 2023 Sep 17.
Medical gases play an important role in the pathophysiology of human diseases and have received extensive attention for their role in neuroprotection. Common pathological mechanisms of spinal cord injury include excitotoxicity, inflammation, cell death, glial scarring, blood-spinal cord barrier disruption, and ischemia/reperfusion injury. Nitric oxide and hydrogen sulfide are important gaseous signaling molecules in living organisms; their pathological role in spinal cord injury models has received more attention in recent years. This study reviews the possible mechanisms of spinal cord injury and the role of nitric oxide and hydrogen sulfide in spinal cord injury.
医疗气体在人类疾病的病理生理学中发挥着重要作用，并且由于其在神经保护中的作用而受到广泛关注。脊髓损伤的常见病理机制包括兴奋性毒性、炎症、细胞死亡、神经胶质瘢痕形成、血脊髓屏障破坏和缺血/再灌注损伤。一氧化氮和硫化氢是生物体中重要的气态信号分子，近年来，它们在脊髓损伤模型中的病理作用受到了更多的关注。本研究综述了脊髓损伤的可能机制以及一氧化氮和硫化氢在脊髓损伤中的作用。
