替卡西林加克拉维酸治疗成年女性社区获得性急性肾盂肾炎的安全性和有效性。

Safety and effectiveness of ticarcillin plus clavulanic acid in the treatment of community-acquired acute pyelonephritis in adult women.

作者信息

Sanders C V, Marier R L, Aldridge K E, Derks F W, Martin D H

出版信息

Am J Med. 1985 Nov 29;79(5B):96-100. doi: 10.1016/0002-9343(85)90139-1.

Abstract

An open study was conducted to evaluate the safety and effectiveness of ticarcillin plus clavulanic acid in the treatment of 18 adult women with community-acquired Escherichia coli acute pyelonephritis. Eleven of the 18 patients had a history of urinary tract infections, primarily acute pyelonephritis. Six patients had blood culture results positive for E. coli in addition to positive urine culture results. Ticarcillin plus clavulanic acid was administered as the 3.2 g formulation to 11 patients and as the 3.1 g formulation to the other seven. The mean duration of treatment was 9.2 days. Five of the 18 (28 percent) patients had clinical and bacteriologic cures; there were 11 (69 percent) relapses or reinfections and two (11 percent) clinical failures. Adverse reactions (all reversible) were reported in 11 (61 percent) patients, the most frequent of which was phlebitis. These results should prompt further investigation into the treatment of acute pyelonephritis with ticarcillin plus clavulanic acid versus other antibiotics.

摘要

开展了一项开放性研究，以评估替卡西林加克拉维酸治疗18例社区获得性大肠杆菌急性肾盂肾炎成年女性患者的安全性和有效性。18例患者中有11例有尿路感染病史，主要是急性肾盂肾炎。6例患者除尿培养结果呈阳性外，血培养结果也显示大肠杆菌阳性。11例患者接受3.2 g制剂的替卡西林加克拉维酸治疗，另外7例接受3.1 g制剂的治疗。平均治疗时长为9.2天。18例患者中有5例（28%）实现临床和细菌学治愈；有11例（69%）复发或再次感染，2例（11%）临床治疗失败。11例（61%）患者报告有不良反应（均为可逆性），最常见的是静脉炎。这些结果应促使对替卡西林加克拉维酸与其他抗生素治疗急性肾盂肾炎的疗效进行进一步研究。